Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes

The pathogenesis of Streptococcus pyogenes (GAS) causing scarlet fever has been associated with the presence of prophages, such as ΦHKU.vir, and their products. Here, the authors characterize the exotoxins SpeC and Spd1 of ΦHKU.vir and show these to act synergistically to facilitate nasopharyngeal c...

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Autores principales:	Stephan Brouwer, Timothy C. Barnett, Diane Ly, Katherine J. Kasper, David M. P. De Oliveira, Tania Rivera-Hernandez, Amanda J. Cork, Liam McIntyre, Magnus G. Jespersen, Johanna Richter, Benjamin L. Schulz, Gordon Dougan, Victor Nizet, Kwok-Yung Yuen, Yuanhai You, John K. McCormick, Martina L. Sanderson-Smith, Mark R. Davies, Mark J. Walker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6e79b1f03e764489835c1a7815d1f404
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spelling	oai:doaj.org-article:6e79b1f03e764489835c1a7815d1f4042021-12-02T18:37:29ZProphage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes10.1038/s41467-020-18700-52041-1723https://doaj.org/article/6e79b1f03e764489835c1a7815d1f4042020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18700-5https://doaj.org/toc/2041-1723The pathogenesis of Streptococcus pyogenes (GAS) causing scarlet fever has been associated with the presence of prophages, such as ΦHKU.vir, and their products. Here, the authors characterize the exotoxins SpeC and Spd1 of ΦHKU.vir and show these to act synergistically to facilitate nasopharyngeal colonization in mice.Stephan BrouwerTimothy C. BarnettDiane LyKatherine J. KasperDavid M. P. De OliveiraTania Rivera-HernandezAmanda J. CorkLiam McIntyreMagnus G. JespersenJohanna RichterBenjamin L. SchulzGordon DouganVictor NizetKwok-Yung YuenYuanhai YouJohn K. McCormickMartina L. Sanderson-SmithMark R. DaviesMark J. WalkerNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stephan Brouwer Timothy C. Barnett Diane Ly Katherine J. Kasper David M. P. De Oliveira Tania Rivera-Hernandez Amanda J. Cork Liam McIntyre Magnus G. Jespersen Johanna Richter Benjamin L. Schulz Gordon Dougan Victor Nizet Kwok-Yung Yuen Yuanhai You John K. McCormick Martina L. Sanderson-Smith Mark R. Davies Mark J. Walker Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes
description	The pathogenesis of Streptococcus pyogenes (GAS) causing scarlet fever has been associated with the presence of prophages, such as ΦHKU.vir, and their products. Here, the authors characterize the exotoxins SpeC and Spd1 of ΦHKU.vir and show these to act synergistically to facilitate nasopharyngeal colonization in mice.
format	article
author	Stephan Brouwer Timothy C. Barnett Diane Ly Katherine J. Kasper David M. P. De Oliveira Tania Rivera-Hernandez Amanda J. Cork Liam McIntyre Magnus G. Jespersen Johanna Richter Benjamin L. Schulz Gordon Dougan Victor Nizet Kwok-Yung Yuen Yuanhai You John K. McCormick Martina L. Sanderson-Smith Mark R. Davies Mark J. Walker
author_facet	Stephan Brouwer Timothy C. Barnett Diane Ly Katherine J. Kasper David M. P. De Oliveira Tania Rivera-Hernandez Amanda J. Cork Liam McIntyre Magnus G. Jespersen Johanna Richter Benjamin L. Schulz Gordon Dougan Victor Nizet Kwok-Yung Yuen Yuanhai You John K. McCormick Martina L. Sanderson-Smith Mark R. Davies Mark J. Walker
author_sort	Stephan Brouwer
title	Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes
title_short	Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes
title_full	Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes
title_fullStr	Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes
title_full_unstemmed	Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes
title_sort	prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing streptococcus pyogenes
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/6e79b1f03e764489835c1a7815d1f404
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Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes

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