Identification of critical amino acid residues in the regulatory N-terminal domain of PMEL
Abstract The pigment cell-specific protein PMEL forms a functional amyloid matrix in melanosomes onto which the pigment melanin is deposited. The amyloid core consists of a short proteolytic fragment, which we have termed the core-amyloid fragment (CAF) and perhaps additional parts of the protein, s...
Enregistré dans:
Auteurs principaux: | Susan M. Mitchell, Morven Graham, Xinran Liu, Ralf M. Leonhardt |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2021
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/6fe1f58f16b744199acb7c25c9e073c8 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
The conserved residue Arg46 in the N-terminal heptad repeat domain of HIV-1 gp41 is critical for viral fusion and entry.
par: Xiaoyi Wang, et autres
Publié: (2012) -
Conformational rearrangement of the NMDA receptor amino-terminal domain during activation and allosteric modulation
par: Vojtech Vyklicky, et autres
Publié: (2021) -
PD-L1 reverses depigmentation in Pmel-1 vitiligo mice by increasing the abundance of Tregs in the skin
par: Xiao Miao, et autres
Publié: (2018) -
Structural Basis for the Differential Regulatory Roles of the PDZ Domain in C-Terminal Processing Proteases
par: Chuang-Kai Chueh, et autres
Publié: (2019) -
Dynamics of SARS-CoV-2 Spike Proteins in Cell Entry: Control Elements in the Amino-Terminal Domains
par: Enya Qing, et autres
Publié: (2021)