Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis

Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis

ABSTRACT Coronaviruses (CoVs) encode a mixture of highly conserved and novel genes, as well as genetic elements necessary for infection and pathogenesis, raising the possibility of common targets for attenuation and therapeutic design. In this study, we focused on highly conserved nonstructural prot...

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Autores principales: Vineet D. Menachery, Lisa E. Gralinski, Hugh D. Mitchell, Kenneth H. Dinnon, Sarah R. Leist, Boyd L. Yount, Rachel L. Graham, Eileen T. McAnarney, Kelly G. Stratton, Adam S. Cockrell, Kari Debbink, Amy C. Sims, Katrina M. Waters, Ralph S. Baric
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2017
Materias:
IFIT
MERS-CoV
SARS-CoV
coronavirus
emerging virus
live attenuated
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/7434bb24ede84ab29da1760f9b1e6e0e
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https://doaj.org/article/7434bb24ede84ab29da1760f9b1e6e0e

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