Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis

Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis

ABSTRACT Coronaviruses (CoVs) encode a mixture of highly conserved and novel genes, as well as genetic elements necessary for infection and pathogenesis, raising the possibility of common targets for attenuation and therapeutic design. In this study, we focused on highly conserved nonstructural prot...

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Bibliographic Details
Main Authors: Vineet D. Menachery, Lisa E. Gralinski, Hugh D. Mitchell, Kenneth H. Dinnon, Sarah R. Leist, Boyd L. Yount, Rachel L. Graham, Eileen T. McAnarney, Kelly G. Stratton, Adam S. Cockrell, Kari Debbink, Amy C. Sims, Katrina M. Waters, Ralph S. Baric
Format: article
Language:EN
Published: American Society for Microbiology 2017
Subjects:
IFIT
MERS-CoV
SARS-CoV
coronavirus
emerging virus
live attenuated
Microbiology
QR1-502
Online Access:https://doaj.org/article/7434bb24ede84ab29da1760f9b1e6e0e
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https://doaj.org/article/7434bb24ede84ab29da1760f9b1e6e0e

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