MTBVAC vaccination protects rhesus macaques against aerosol challenge with M. tuberculosis and induces immune signatures analogous to those observed in clinical studies

MTBVAC vaccination protects rhesus macaques against aerosol challenge with M. tuberculosis and induces immune signatures analogous to those observed in clinical studies

Abstract A single intradermal vaccination with MTBVAC given to adult rhesus macaques was well tolerated and conferred a significant improvement in outcome following aerosol exposure to M. tuberculosis compared to that provided by a single BCG vaccination. Vaccination with MTBVAC resulted in a signif...

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Bibliographic Details
Main Authors: Andrew D. White, Laura Sibley, Charlotte Sarfas, Alexandra Morrison, Jennie Gullick, Simon Clark, Fergus Gleeson, Anthony McIntyre, Cecilia Lindestam Arlehamn, Alessandro Sette, Francisco J. Salguero, Emma Rayner, Esteban Rodriguez, Eugenia Puentes, Dominick Laddy, Ann Williams, Mike Dennis, Carlos Martin, Sally Sharpe
Format: article
Language:EN
Published: Nature Portfolio 2021
Subjects:
Immunologic diseases. Allergy
RC581-607
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Online Access:https://doaj.org/article/75a0f9423daa48f5b1801560e5f933f6
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https://doaj.org/article/75a0f9423daa48f5b1801560e5f933f6

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