DNA polymerase ε relies on a unique domain for efficient replisome assembly and strand synthesis
DNA polymerase epsilon (Pol ε) synthesizes half of the genome in every cell cycle. Here the authors uncover a dual role of a unique domain within the Pol ε catalytic core in replisome assembly and DNA synthesis and the impact of this domain on genome stability.
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| Auteurs principaux: | , , , , , , |
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| Format: | article |
| Langue: | EN |
| Publié: |
Nature Portfolio
2020
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| Accès en ligne: | https://doaj.org/article/784f3f5d0e034b3d9506e9710237067b |
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| Résumé: | DNA polymerase epsilon (Pol ε) synthesizes half of the genome in every cell cycle. Here the authors uncover a dual role of a unique domain within the Pol ε catalytic core in replisome assembly and DNA synthesis and the impact of this domain on genome stability. |
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