Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion
Senoo et al. describe a chemical fragment that disrupts dimerization of P-cadherin. In doing so, this fragment inhibits cadherin-mediated cell-adhesion and aggregation.
Enregistré dans:
Auteurs principaux: | Akinobu Senoo, Sho Ito, Satoru Nagatoishi, Yutaro Saito, Go Ueno, Daisuke Kuroda, Kouhei Yoshida, Takumi Tashima, Shota Kudo, Shinsuke Sando, Kouhei Tsumoto |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2021
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/78b79e1b2b4e4736a8a8908c4e78773c |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Design strategy for serine hydroxymethyltransferase probes based on retro-aldol-type reaction
par: Hiroshi Nonaka, et autres
Publié: (2019) -
A glutamine sensor that directly activates TORC1
par: Mirai Tanigawa, et autres
Publié: (2021) -
Affinity improvement of a therapeutic antibody by structure-based computational design: generation of electrostatic interactions in the transition state stabilizes the antibody-antigen complex.
par: Masato Kiyoshi, et autres
Publié: (2014) -
Heme controls the structural rearrangement of its sensor protein mediating the hemolytic bacterial survival
par: Megumi Nishinaga, et autres
Publié: (2021) -
The transcriptional corepressor CtBP2 serves as a metabolite sensor orchestrating hepatic glucose and lipid homeostasis
par: Motohiro Sekiya, et autres
Publié: (2021)