TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments

The RNA binding protein TRBP is a component of the Dicer complex but its role in microRNA biogenesis remains poorly understood. Here the authors use a crowded RNA environment and single-molecule imaging to show that TRBP acts as a gatekeeper to prevent Dicer engagement with pre miRNA-like substrates...

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Bibliographic Details
Main Authors: Mohamed Fareh, Kyu-Hyeon Yeom, Anna C. Haagsma, Sweeny Chauhan, Inha Heo, Chirlmin Joo
Format: article
Language:EN
Published: Nature Portfolio 2016
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Online Access:https://doaj.org/article/7b1687162fec4a0bb83eed9b2f3f28d3
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