TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments

The RNA binding protein TRBP is a component of the Dicer complex but its role in microRNA biogenesis remains poorly understood. Here the authors use a crowded RNA environment and single-molecule imaging to show that TRBP acts as a gatekeeper to prevent Dicer engagement with pre miRNA-like substrates...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mohamed Fareh, Kyu-Hyeon Yeom, Anna C. Haagsma, Sweeny Chauhan, Inha Heo, Chirlmin Joo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7b1687162fec4a0bb83eed9b2f3f28d3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7b1687162fec4a0bb83eed9b2f3f28d3
record_format	dspace
spelling	oai:doaj.org-article:7b1687162fec4a0bb83eed9b2f3f28d32021-12-02T14:39:13ZTRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments10.1038/ncomms136942041-1723https://doaj.org/article/7b1687162fec4a0bb83eed9b2f3f28d32016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13694https://doaj.org/toc/2041-1723The RNA binding protein TRBP is a component of the Dicer complex but its role in microRNA biogenesis remains poorly understood. Here the authors use a crowded RNA environment and single-molecule imaging to show that TRBP acts as a gatekeeper to prevent Dicer engagement with pre miRNA-like substrates.Mohamed FarehKyu-Hyeon YeomAnna C. HaagsmaSweeny ChauhanInha HeoChirlmin JooNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Mohamed Fareh Kyu-Hyeon Yeom Anna C. Haagsma Sweeny Chauhan Inha Heo Chirlmin Joo TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments
description	The RNA binding protein TRBP is a component of the Dicer complex but its role in microRNA biogenesis remains poorly understood. Here the authors use a crowded RNA environment and single-molecule imaging to show that TRBP acts as a gatekeeper to prevent Dicer engagement with pre miRNA-like substrates.
format	article
author	Mohamed Fareh Kyu-Hyeon Yeom Anna C. Haagsma Sweeny Chauhan Inha Heo Chirlmin Joo
author_facet	Mohamed Fareh Kyu-Hyeon Yeom Anna C. Haagsma Sweeny Chauhan Inha Heo Chirlmin Joo
author_sort	Mohamed Fareh
title	TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments
title_short	TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments
title_full	TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments
title_fullStr	TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments
title_full_unstemmed	TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments
title_sort	trbp ensures efficient dicer processing of precursor microrna in rna-crowded environments
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/7b1687162fec4a0bb83eed9b2f3f28d3
work_keys_str_mv	AT mohamedfareh trbpensuresefficientdicerprocessingofprecursormicrornainrnacrowdedenvironments AT kyuhyeonyeom trbpensuresefficientdicerprocessingofprecursormicrornainrnacrowdedenvironments AT annachaagsma trbpensuresefficientdicerprocessingofprecursormicrornainrnacrowdedenvironments AT sweenychauhan trbpensuresefficientdicerprocessingofprecursormicrornainrnacrowdedenvironments AT inhaheo trbpensuresefficientdicerprocessingofprecursormicrornainrnacrowdedenvironments AT chirlminjoo trbpensuresefficientdicerprocessingofprecursormicrornainrnacrowdedenvironments
_version_	1718390722020769792

TRBP ensures efficient Dicer processing of precursor microRNA in RNA-crowded environments

Ejemplares similares