Geometrically defined environments direct cell division rate and subcellular YAP localization in single mouse embryonic stem cells

Geometrically defined environments direct cell division rate and subcellular YAP localization in single mouse embryonic stem cells

Abstract Mechanotransduction via yes-associated protein (YAP) is a central mechanism for decision-making in mouse embryonic stem cells (mESCs). Nuclear localization of YAP is tightly connected to pluripotency and increases the cell division rate (CDR). How the geometry of the extracellular environme...

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Auteurs principaux: Sarah Bertels, Mona Jaggy, Benjamin Richter, Stephan Keppler, Kerstin Weber, Elisa Genthner, Andrea C. Fischer, Michael Thiel, Martin Wegener, Alexandra M. Greiner, Tatjana J. Autenrieth, Martin Bastmeyer
Format: article
Langue:EN
Publié: Nature Portfolio 2021
Sujets:
Medicine
R
Science
Q
Accès en ligne:https://doaj.org/article/80ffe03679444a2aa6e0e27b7e0d2b1e
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