Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1

Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1

Additional sex combs-like (ASXLs) stimulate BAP1 deubiquitinase activity to induce tumor suppression, but how these complexes work in coordination in vivo is unclear. Here, the authors show the mutually reinforcing roles of BAP1 and ASXLs such that BAP1 promotes DEUBAD monoubiquitination of ASXL2, w...

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Main Authors: Salima Daou, Haithem Barbour, Oumaima Ahmed, Louis Masclef, Caroline Baril, Nadine Sen Nkwe, Daméhan Tchelougou, Maxime Uriarte, Eric Bonneil, Derek Ceccarelli, Nazar Mashtalir, Mika Tanji, Jean-Yves Masson, Pierre Thibault, Frank Sicheri, Haining Yang, Michele Carbone, Marc Therrien, El Bachir Affar
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
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Online Access:https://doaj.org/article/814d9c18ef9a493e9a4123fb81cb86a6
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https://doaj.org/article/814d9c18ef9a493e9a4123fb81cb86a6

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