Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1

Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1

Additional sex combs-like (ASXLs) stimulate BAP1 deubiquitinase activity to induce tumor suppression, but how these complexes work in coordination in vivo is unclear. Here, the authors show the mutually reinforcing roles of BAP1 and ASXLs such that BAP1 promotes DEUBAD monoubiquitination of ASXL2, w...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Salima Daou, Haithem Barbour, Oumaima Ahmed, Louis Masclef, Caroline Baril, Nadine Sen Nkwe, Daméhan Tchelougou, Maxime Uriarte, Eric Bonneil, Derek Ceccarelli, Nazar Mashtalir, Mika Tanji, Jean-Yves Masson, Pierre Thibault, Frank Sicheri, Haining Yang, Michele Carbone, Marc Therrien, El Bachir Affar
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/814d9c18ef9a493e9a4123fb81cb86a6
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:814d9c18ef9a493e9a4123fb81cb86a6
record_format dspace
spelling oai:doaj.org-article:814d9c18ef9a493e9a4123fb81cb86a62021-12-02T16:49:51ZMonoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP110.1038/s41467-018-06854-22041-1723https://doaj.org/article/814d9c18ef9a493e9a4123fb81cb86a62018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06854-2https://doaj.org/toc/2041-1723Additional sex combs-like (ASXLs) stimulate BAP1 deubiquitinase activity to induce tumor suppression, but how these complexes work in coordination in vivo is unclear. Here, the authors show the mutually reinforcing roles of BAP1 and ASXLs such that BAP1 promotes DEUBAD monoubiquitination of ASXL2, which in turn stimulates BAP1 DUB activity.Salima DaouHaithem BarbourOumaima AhmedLouis MasclefCaroline BarilNadine Sen NkweDaméhan TchelougouMaxime UriarteEric BonneilDerek CeccarelliNazar MashtalirMika TanjiJean-Yves MassonPierre ThibaultFrank SicheriHaining YangMichele CarboneMarc TherrienEl Bachir AffarNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-21 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Salima Daou
Haithem Barbour
Oumaima Ahmed
Louis Masclef
Caroline Baril
Nadine Sen Nkwe
Daméhan Tchelougou
Maxime Uriarte
Eric Bonneil
Derek Ceccarelli
Nazar Mashtalir
Mika Tanji
Jean-Yves Masson
Pierre Thibault
Frank Sicheri
Haining Yang
Michele Carbone
Marc Therrien
El Bachir Affar
Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
description Additional sex combs-like (ASXLs) stimulate BAP1 deubiquitinase activity to induce tumor suppression, but how these complexes work in coordination in vivo is unclear. Here, the authors show the mutually reinforcing roles of BAP1 and ASXLs such that BAP1 promotes DEUBAD monoubiquitination of ASXL2, which in turn stimulates BAP1 DUB activity.
format article
author Salima Daou
Haithem Barbour
Oumaima Ahmed
Louis Masclef
Caroline Baril
Nadine Sen Nkwe
Daméhan Tchelougou
Maxime Uriarte
Eric Bonneil
Derek Ceccarelli
Nazar Mashtalir
Mika Tanji
Jean-Yves Masson
Pierre Thibault
Frank Sicheri
Haining Yang
Michele Carbone
Marc Therrien
El Bachir Affar
author_facet Salima Daou
Haithem Barbour
Oumaima Ahmed
Louis Masclef
Caroline Baril
Nadine Sen Nkwe
Daméhan Tchelougou
Maxime Uriarte
Eric Bonneil
Derek Ceccarelli
Nazar Mashtalir
Mika Tanji
Jean-Yves Masson
Pierre Thibault
Frank Sicheri
Haining Yang
Michele Carbone
Marc Therrien
El Bachir Affar
author_sort Salima Daou
title Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
title_short Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
title_full Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
title_fullStr Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
title_full_unstemmed Monoubiquitination of ASXLs controls the deubiquitinase activity of the tumor suppressor BAP1
title_sort monoubiquitination of asxls controls the deubiquitinase activity of the tumor suppressor bap1
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/814d9c18ef9a493e9a4123fb81cb86a6
work_keys_str_mv AT salimadaou monoubiquitinationofasxlscontrolsthedeubiquitinaseactivityofthetumorsuppressorbap1
AT haithembarbour monoubiquitinationofasxlscontrolsthedeubiquitinaseactivityofthetumorsuppressorbap1
AT oumaimaahmed monoubiquitinationofasxlscontrolsthedeubiquitinaseactivityofthetumorsuppressorbap1
AT louismasclef monoubiquitinationofasxlscontrolsthedeubiquitinaseactivityofthetumorsuppressorbap1
AT carolinebaril monoubiquitinationofasxlscontrolsthedeubiquitinaseactivityofthetumorsuppressorbap1
AT nadinesennkwe monoubiquitinationofasxlscontrolsthedeubiquitinaseactivityofthetumorsuppressorbap1
AT damehantchelougou monoubiquitinationofasxlscontrolsthedeubiquitinaseactivityofthetumorsuppressorbap1
AT maximeuriarte monoubiquitinationofasxlscontrolsthedeubiquitinaseactivityofthetumorsuppressorbap1
AT ericbonneil monoubiquitinationofasxlscontrolsthedeubiquitinaseactivityofthetumorsuppressorbap1
AT derekceccarelli monoubiquitinationofasxlscontrolsthedeubiquitinaseactivityofthetumorsuppressorbap1
AT nazarmashtalir monoubiquitinationofasxlscontrolsthedeubiquitinaseactivityofthetumorsuppressorbap1
AT mikatanji monoubiquitinationofasxlscontrolsthedeubiquitinaseactivityofthetumorsuppressorbap1
AT jeanyvesmasson monoubiquitinationofasxlscontrolsthedeubiquitinaseactivityofthetumorsuppressorbap1
AT pierrethibault monoubiquitinationofasxlscontrolsthedeubiquitinaseactivityofthetumorsuppressorbap1
AT franksicheri monoubiquitinationofasxlscontrolsthedeubiquitinaseactivityofthetumorsuppressorbap1
AT hainingyang monoubiquitinationofasxlscontrolsthedeubiquitinaseactivityofthetumorsuppressorbap1
AT michelecarbone monoubiquitinationofasxlscontrolsthedeubiquitinaseactivityofthetumorsuppressorbap1
AT marctherrien monoubiquitinationofasxlscontrolsthedeubiquitinaseactivityofthetumorsuppressorbap1
AT elbachiraffar monoubiquitinationofasxlscontrolsthedeubiquitinaseactivityofthetumorsuppressorbap1
_version_ 1718383225291669504

Ejemplares similares