Host and viral determinants for efficient SARS-CoV-2 infection of the human lung

Here, using lung epithelial cells and ex vivo tissue explants, the authors show that, in addition to ACE2, host heparan sulfate is directly involved in SARS-CoV-2 attachment and entry and provide data suggesting that host sialic acids may act as viral restriction factor in lung tissues.

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Autores principales:	Hin Chu, Bingjie Hu, Xiner Huang, Yue Chai, Dongyan Zhou, Yixin Wang, Huiping Shuai, Dong Yang, Yuxin Hou, Xi Zhang, Terrence Tsz-Tai Yuen, Jian-Piao Cai, Anna Jinxia Zhang, Jie Zhou, Shuofeng Yuan, Kelvin Kai-Wang To, Ivy Hau-Yee Chan, Ko-Yung Sit, Dominic Chi-Chung Foo, Ian Yu-Hong Wong, Ada Tsui-Lin Ng, Tan To Cheung, Simon Ying-Kit Law, Wing-Kuk Au, Melinda A. Brindley, Zhiwei Chen, Kin-Hang Kok, Jasper Fuk-Woo Chan, Kwok-Yung Yuen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/81bdbff8c7524b069f430bb69d6fb811
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spelling	oai:doaj.org-article:81bdbff8c7524b069f430bb69d6fb8112021-12-02T15:16:23ZHost and viral determinants for efficient SARS-CoV-2 infection of the human lung10.1038/s41467-020-20457-w2041-1723https://doaj.org/article/81bdbff8c7524b069f430bb69d6fb8112021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20457-whttps://doaj.org/toc/2041-1723Here, using lung epithelial cells and ex vivo tissue explants, the authors show that, in addition to ACE2, host heparan sulfate is directly involved in SARS-CoV-2 attachment and entry and provide data suggesting that host sialic acids may act as viral restriction factor in lung tissues.Hin ChuBingjie HuXiner HuangYue ChaiDongyan ZhouYixin WangHuiping ShuaiDong YangYuxin HouXi ZhangTerrence Tsz-Tai YuenJian-Piao CaiAnna Jinxia ZhangJie ZhouShuofeng YuanKelvin Kai-Wang ToIvy Hau-Yee ChanKo-Yung SitDominic Chi-Chung FooIan Yu-Hong WongAda Tsui-Lin NgTan To CheungSimon Ying-Kit LawWing-Kuk AuMelinda A. BrindleyZhiwei ChenKin-Hang KokJasper Fuk-Woo ChanKwok-Yung YuenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hin Chu Bingjie Hu Xiner Huang Yue Chai Dongyan Zhou Yixin Wang Huiping Shuai Dong Yang Yuxin Hou Xi Zhang Terrence Tsz-Tai Yuen Jian-Piao Cai Anna Jinxia Zhang Jie Zhou Shuofeng Yuan Kelvin Kai-Wang To Ivy Hau-Yee Chan Ko-Yung Sit Dominic Chi-Chung Foo Ian Yu-Hong Wong Ada Tsui-Lin Ng Tan To Cheung Simon Ying-Kit Law Wing-Kuk Au Melinda A. Brindley Zhiwei Chen Kin-Hang Kok Jasper Fuk-Woo Chan Kwok-Yung Yuen Host and viral determinants for efficient SARS-CoV-2 infection of the human lung
description	Here, using lung epithelial cells and ex vivo tissue explants, the authors show that, in addition to ACE2, host heparan sulfate is directly involved in SARS-CoV-2 attachment and entry and provide data suggesting that host sialic acids may act as viral restriction factor in lung tissues.
format	article
author	Hin Chu Bingjie Hu Xiner Huang Yue Chai Dongyan Zhou Yixin Wang Huiping Shuai Dong Yang Yuxin Hou Xi Zhang Terrence Tsz-Tai Yuen Jian-Piao Cai Anna Jinxia Zhang Jie Zhou Shuofeng Yuan Kelvin Kai-Wang To Ivy Hau-Yee Chan Ko-Yung Sit Dominic Chi-Chung Foo Ian Yu-Hong Wong Ada Tsui-Lin Ng Tan To Cheung Simon Ying-Kit Law Wing-Kuk Au Melinda A. Brindley Zhiwei Chen Kin-Hang Kok Jasper Fuk-Woo Chan Kwok-Yung Yuen
author_facet	Hin Chu Bingjie Hu Xiner Huang Yue Chai Dongyan Zhou Yixin Wang Huiping Shuai Dong Yang Yuxin Hou Xi Zhang Terrence Tsz-Tai Yuen Jian-Piao Cai Anna Jinxia Zhang Jie Zhou Shuofeng Yuan Kelvin Kai-Wang To Ivy Hau-Yee Chan Ko-Yung Sit Dominic Chi-Chung Foo Ian Yu-Hong Wong Ada Tsui-Lin Ng Tan To Cheung Simon Ying-Kit Law Wing-Kuk Au Melinda A. Brindley Zhiwei Chen Kin-Hang Kok Jasper Fuk-Woo Chan Kwok-Yung Yuen
author_sort	Hin Chu
title	Host and viral determinants for efficient SARS-CoV-2 infection of the human lung
title_short	Host and viral determinants for efficient SARS-CoV-2 infection of the human lung
title_full	Host and viral determinants for efficient SARS-CoV-2 infection of the human lung
title_fullStr	Host and viral determinants for efficient SARS-CoV-2 infection of the human lung
title_full_unstemmed	Host and viral determinants for efficient SARS-CoV-2 infection of the human lung
title_sort	host and viral determinants for efficient sars-cov-2 infection of the human lung
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/81bdbff8c7524b069f430bb69d6fb811
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Host and viral determinants for efficient SARS-CoV-2 infection of the human lung

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