Sequestration by IFIT1 impairs translation of 2'O-unmethylated capped RNA.

Viruses that generate capped RNA lacking 2'O methylation on the first ribose are severely affected by the antiviral activity of Type I interferons. We used proteome-wide affinity purification coupled to mass spectrometry to identify human and mouse proteins specifically binding to capped RNA wi...

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Autores principales: Matthias Habjan, Philipp Hubel, Livia Lacerda, Christian Benda, Cathleen Holze, Christian H Eberl, Angelika Mann, Eveline Kindler, Cristina Gil-Cruz, John Ziebuhr, Volker Thiel, Andreas Pichlmair
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2013
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Acceso en línea:https://doaj.org/article/84761bfef68c48ab8b7cff68a5fa0d6c
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