Development of small molecule inhibitors targeting PBX1 transcription signaling as a novel cancer therapeutic strategy
Summary: PBX1 is a transcription factor involved in diverse cellular functions including organ development, stem cell renewal, and tumorigenesis. PBX1 is localized at chr1q23.3, a frequently amplified chromosomal region, and it is overexpressed in many human malignancies. Cancer cells with elevated...
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Autores principales: | , , , , , , , , , , |
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Formato: | article |
Lenguaje: | EN |
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Elsevier
2021
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Materias: | |
Acceso en línea: | https://doaj.org/article/8619e16c5d294c30acce63292715bdfb |
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