Development of small molecule inhibitors targeting PBX1 transcription signaling as a novel cancer therapeutic strategy

Summary: PBX1 is a transcription factor involved in diverse cellular functions including organ development, stem cell renewal, and tumorigenesis. PBX1 is localized at chr1q23.3, a frequently amplified chromosomal region, and it is overexpressed in many human malignancies. Cancer cells with elevated...

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Autores principales: Yao-An Shen, Jin Jung, Geoffrey D. Shimberg, Fang-Chi Hsu, Yohan Suryo Rahmanto, Stephanie L. Gaillard, Jiaxin Hong, Jürgen Bosch, Ie-Ming Shih, Chi-Mu Chuang, Tian-Li Wang
Formato: article
Lenguaje:EN
Publicado: Elsevier 2021
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Acceso en línea:https://doaj.org/article/8619e16c5d294c30acce63292715bdfb
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