Precision cancer therapy is impacted by oncogene-dependent epigenome remodeling

Abstract The cancer genome provides the blueprint for identifying oncogenic mutations driving tumor growth and these mutant proteins and pathways are the targets for precision cancer therapies. However, many oncogenes are capable of reprogramming the landscape of active portion of the genome, common...

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Autores principales:	Feng Liu, Paul S. Mischel, Webster K. Cavenee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/8741ff04de824f7585fff1793dbafe1b
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spelling	oai:doaj.org-article:8741ff04de824f7585fff1793dbafe1b2021-12-02T13:41:45ZPrecision cancer therapy is impacted by oncogene-dependent epigenome remodeling10.1038/s41698-017-0005-22397-768Xhttps://doaj.org/article/8741ff04de824f7585fff1793dbafe1b2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41698-017-0005-2https://doaj.org/toc/2397-768XAbstract The cancer genome provides the blueprint for identifying oncogenic mutations driving tumor growth and these mutant proteins and pathways are the targets for precision cancer therapies. However, many oncogenes are capable of reprogramming the landscape of active portion of the genome, commonly known as the epigenome. This creates fluidity, and thereby heterogeneity, that demands consideration of this additional layer of complexity for effective therapeutic design and application. Molecular dissection of the epigenome may identify oncogene-induced, actionable vulnerabilities, broadening the spectrum of precision oncology treatments.Feng LiuPaul S. MischelWebster K. CaveneeNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Precision Oncology, Vol 1, Iss 1, Pp 1-5 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Feng Liu Paul S. Mischel Webster K. Cavenee Precision cancer therapy is impacted by oncogene-dependent epigenome remodeling
description	Abstract The cancer genome provides the blueprint for identifying oncogenic mutations driving tumor growth and these mutant proteins and pathways are the targets for precision cancer therapies. However, many oncogenes are capable of reprogramming the landscape of active portion of the genome, commonly known as the epigenome. This creates fluidity, and thereby heterogeneity, that demands consideration of this additional layer of complexity for effective therapeutic design and application. Molecular dissection of the epigenome may identify oncogene-induced, actionable vulnerabilities, broadening the spectrum of precision oncology treatments.
format	article
author	Feng Liu Paul S. Mischel Webster K. Cavenee
author_facet	Feng Liu Paul S. Mischel Webster K. Cavenee
author_sort	Feng Liu
title	Precision cancer therapy is impacted by oncogene-dependent epigenome remodeling
title_short	Precision cancer therapy is impacted by oncogene-dependent epigenome remodeling
title_full	Precision cancer therapy is impacted by oncogene-dependent epigenome remodeling
title_fullStr	Precision cancer therapy is impacted by oncogene-dependent epigenome remodeling
title_full_unstemmed	Precision cancer therapy is impacted by oncogene-dependent epigenome remodeling
title_sort	precision cancer therapy is impacted by oncogene-dependent epigenome remodeling
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8741ff04de824f7585fff1793dbafe1b
work_keys_str_mv	AT fengliu precisioncancertherapyisimpactedbyoncogenedependentepigenomeremodeling AT paulsmischel precisioncancertherapyisimpactedbyoncogenedependentepigenomeremodeling AT websterkcavenee precisioncancertherapyisimpactedbyoncogenedependentepigenomeremodeling
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Precision cancer therapy is impacted by oncogene-dependent epigenome remodeling

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