Regulatory T cells trigger effector T cell DNA damage and senescence caused by metabolic competition
Regulatory T (Treg) cells can induce senescence of tumour-associated effector T cells, but it is not clear how. Here the authors show that Treg cells outcompete effector T cells for glucose uptake, resulting in activation of the DNA damage response in effector T cells.
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | article |
| Language: | EN |
| Published: |
Nature Portfolio
2018
|
| Subjects: | |
| Online Access: | https://doaj.org/article/8b3bbe54a08b4d00adeca8ec2f0f310b |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|