A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids

A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids

CD1 proteins present lipid antigens to T cells via the T cell receptor. Here the authors describe T cell reactivity to human membrane lipid moieties and provide structural data to define a molecular mechanism of promiscuous recognition of self-derived phospholipids.

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Detalles Bibliográficos
Autores principales: Adam Shahine, Peter Reinink, Josephine F. Reijneveld, Stephanie Gras, Mira Holzheimer, Tan-Yun Cheng, Adriaan J. Minnaard, John D. Altman, Steffi Lenz, Jacques Prandi, Joanna Kubler-Kielb, D. Branch Moody, Jamie Rossjohn, Ildiko Van Rhijn
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/8b688ab776554395acd758b05b541c3e
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Descripción
Sumario:CD1 proteins present lipid antigens to T cells via the T cell receptor. Here the authors describe T cell reactivity to human membrane lipid moieties and provide structural data to define a molecular mechanism of promiscuous recognition of self-derived phospholipids.

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