A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids

CD1 proteins present lipid antigens to T cells via the T cell receptor. Here the authors describe T cell reactivity to human membrane lipid moieties and provide structural data to define a molecular mechanism of promiscuous recognition of self-derived phospholipids.

Guardado en:

Detalles Bibliográficos
Autores principales:	Adam Shahine, Peter Reinink, Josephine F. Reijneveld, Stephanie Gras, Mira Holzheimer, Tan-Yun Cheng, Adriaan J. Minnaard, John D. Altman, Steffi Lenz, Jacques Prandi, Joanna Kubler-Kielb, D. Branch Moody, Jamie Rossjohn, Ildiko Van Rhijn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8b688ab776554395acd758b05b541c3e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:8b688ab776554395acd758b05b541c3e
record_format	dspace
spelling	oai:doaj.org-article:8b688ab776554395acd758b05b541c3e2021-12-02T17:01:55ZA T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids10.1038/s41467-018-07898-02041-1723https://doaj.org/article/8b688ab776554395acd758b05b541c3e2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07898-0https://doaj.org/toc/2041-1723CD1 proteins present lipid antigens to T cells via the T cell receptor. Here the authors describe T cell reactivity to human membrane lipid moieties and provide structural data to define a molecular mechanism of promiscuous recognition of self-derived phospholipids.Adam ShahinePeter ReininkJosephine F. ReijneveldStephanie GrasMira HolzheimerTan-Yun ChengAdriaan J. MinnaardJohn D. AltmanSteffi LenzJacques PrandiJoanna Kubler-KielbD. Branch MoodyJamie RossjohnIldiko Van RhijnNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Adam Shahine Peter Reinink Josephine F. Reijneveld Stephanie Gras Mira Holzheimer Tan-Yun Cheng Adriaan J. Minnaard John D. Altman Steffi Lenz Jacques Prandi Joanna Kubler-Kielb D. Branch Moody Jamie Rossjohn Ildiko Van Rhijn A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids
description	CD1 proteins present lipid antigens to T cells via the T cell receptor. Here the authors describe T cell reactivity to human membrane lipid moieties and provide structural data to define a molecular mechanism of promiscuous recognition of self-derived phospholipids.
format	article
author	Adam Shahine Peter Reinink Josephine F. Reijneveld Stephanie Gras Mira Holzheimer Tan-Yun Cheng Adriaan J. Minnaard John D. Altman Steffi Lenz Jacques Prandi Joanna Kubler-Kielb D. Branch Moody Jamie Rossjohn Ildiko Van Rhijn
author_facet	Adam Shahine Peter Reinink Josephine F. Reijneveld Stephanie Gras Mira Holzheimer Tan-Yun Cheng Adriaan J. Minnaard John D. Altman Steffi Lenz Jacques Prandi Joanna Kubler-Kielb D. Branch Moody Jamie Rossjohn Ildiko Van Rhijn
author_sort	Adam Shahine
title	A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids
title_short	A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids
title_full	A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids
title_fullStr	A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids
title_full_unstemmed	A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids
title_sort	t-cell receptor escape channel allows broad t-cell response to cd1b and membrane phospholipids
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8b688ab776554395acd758b05b541c3e
work_keys_str_mv	AT adamshahine atcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT peterreinink atcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT josephinefreijneveld atcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT stephaniegras atcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT miraholzheimer atcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT tanyuncheng atcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT adriaanjminnaard atcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT johndaltman atcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT steffilenz atcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT jacquesprandi atcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT joannakublerkielb atcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT dbranchmoody atcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT jamierossjohn atcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT ildikovanrhijn atcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT adamshahine tcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT peterreinink tcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT josephinefreijneveld tcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT stephaniegras tcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT miraholzheimer tcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT tanyuncheng tcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT adriaanjminnaard tcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT johndaltman tcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT steffilenz tcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT jacquesprandi tcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT joannakublerkielb tcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT dbranchmoody tcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT jamierossjohn tcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids AT ildikovanrhijn tcellreceptorescapechannelallowsbroadtcellresponsetocd1bandmembranephospholipids
_version_	1718382039876501504

A T-cell receptor escape channel allows broad T-cell response to CD1b and membrane phospholipids

Ejemplares similares