Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry
Temsavir, a compound that inhibits HIV entry by binding envelope (Env), is currently in clinical development. Here, Lai et al. identify a more than 10-fold improved compound and, using lattice engineering, obtain crystal structures that give insights into improved inhibition between small molecules...
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| Auteurs principaux: | , , , , , , , , , , , , , , , , , , , |
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| Format: | article |
| Langue: | EN |
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Nature Portfolio
2019
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| Accès en ligne: | https://doaj.org/article/8c1780f80cef41df909afde553e1a2ab |
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