Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry

Temsavir, a compound that inhibits HIV entry by binding envelope (Env), is currently in clinical development. Here, Lai et al. identify a more than 10-fold improved compound and, using lattice engineering, obtain crystal structures that give insights into improved inhibition between small molecules...

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Autores principales:	Yen-Ting Lai, Tao Wang, Sijy O’Dell, Mark K. Louder, Arne Schön, Crystal S. F. Cheung, Gwo-Yu Chuang, Aliaksandr Druz, Bob Lin, Krisha McKee, Dongjun Peng, Yongping Yang, Baoshan Zhang, Alon Herschhorn, Joseph Sodroski, Robert T. Bailer, Nicole A. Doria-Rose, John R. Mascola, David R. Langley, Peter D. Kwong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8c1780f80cef41df909afde553e1a2ab
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spelling	oai:doaj.org-article:8c1780f80cef41df909afde553e1a2ab2021-12-02T14:39:16ZLattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry10.1038/s41467-018-07851-12041-1723https://doaj.org/article/8c1780f80cef41df909afde553e1a2ab2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07851-1https://doaj.org/toc/2041-1723Temsavir, a compound that inhibits HIV entry by binding envelope (Env), is currently in clinical development. Here, Lai et al. identify a more than 10-fold improved compound and, using lattice engineering, obtain crystal structures that give insights into improved inhibition between small molecules and Env.Yen-Ting LaiTao WangSijy O’DellMark K. LouderArne SchönCrystal S. F. CheungGwo-Yu ChuangAliaksandr DruzBob LinKrisha McKeeDongjun PengYongping YangBaoshan ZhangAlon HerschhornJoseph SodroskiRobert T. BailerNicole A. Doria-RoseJohn R. MascolaDavid R. LangleyPeter D. KwongNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yen-Ting Lai Tao Wang Sijy O’Dell Mark K. Louder Arne Schön Crystal S. F. Cheung Gwo-Yu Chuang Aliaksandr Druz Bob Lin Krisha McKee Dongjun Peng Yongping Yang Baoshan Zhang Alon Herschhorn Joseph Sodroski Robert T. Bailer Nicole A. Doria-Rose John R. Mascola David R. Langley Peter D. Kwong Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry
description	Temsavir, a compound that inhibits HIV entry by binding envelope (Env), is currently in clinical development. Here, Lai et al. identify a more than 10-fold improved compound and, using lattice engineering, obtain crystal structures that give insights into improved inhibition between small molecules and Env.
format	article
author	Yen-Ting Lai Tao Wang Sijy O’Dell Mark K. Louder Arne Schön Crystal S. F. Cheung Gwo-Yu Chuang Aliaksandr Druz Bob Lin Krisha McKee Dongjun Peng Yongping Yang Baoshan Zhang Alon Herschhorn Joseph Sodroski Robert T. Bailer Nicole A. Doria-Rose John R. Mascola David R. Langley Peter D. Kwong
author_facet	Yen-Ting Lai Tao Wang Sijy O’Dell Mark K. Louder Arne Schön Crystal S. F. Cheung Gwo-Yu Chuang Aliaksandr Druz Bob Lin Krisha McKee Dongjun Peng Yongping Yang Baoshan Zhang Alon Herschhorn Joseph Sodroski Robert T. Bailer Nicole A. Doria-Rose John R. Mascola David R. Langley Peter D. Kwong
author_sort	Yen-Ting Lai
title	Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry
title_short	Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry
title_full	Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry
title_fullStr	Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry
title_full_unstemmed	Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry
title_sort	lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of hiv-1 entry
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/8c1780f80cef41df909afde553e1a2ab
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Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry

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