Essential structural elements in tRNAPro for EF-P-mediated alleviation of translation stalling

Ribosomes tend to stall during the translation of consecutive proline residues, which can be rescued by the co-translational factor EF-P. Here the authors identify a structural element of tRNAProresponsible for specific recognition by EF-P and stimulation of Pro-Pro peptide bond formation.

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Autores principales: Takayuki Katoh, Ingo Wohlgemuth, Masanobu Nagano, Marina V. Rodnina, Hiroaki Suga
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/90d8b72d78184e6a839f81702aa64ca5
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