IMBALANCE IN IL-2 AND IL-4 PRODUCTION AND RECEPTION DURING PROLONGED VIRAL ANTIGENEMIA IN TICK-BORN ENCEPHALITIS
Abastract. The aim of present study was to evaluate a role of certain key immunoregulatory cytokines, IL-2 and IL-4, in development of disturbed intercellular cooperation of immunocytes during long-term antigenemia in tick-borne encephalitis infection. By means of novel immunological and molecular b...
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Autores principales: | , , , , , , |
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Formato: | article |
Lenguaje: | RU |
Publicado: |
SPb RAACI
2014
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Materias: | |
Acceso en línea: | https://doaj.org/article/92544f51ec9146ae955291259adc0876 |
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Sumario: | Abastract. The aim of present study was to evaluate a role of certain key immunoregulatory cytokines, IL-2 and IL-4, in development of disturbed intercellular cooperation of immunocytes during long-term antigenemia in tick-borne encephalitis infection. By means of novel immunological and molecular biology testing techniques, an imbalance in production and reception of Th1- and Th2-cytokines (resp., IL-2 and IL-4) by mononuclear leukocytes from peripheral blood towards Th2 response was found in cases of prolonged tick-borne encephalitis viral antigenemia. The study has revealed that, when analyzing effects of IL-4 gene polymorphisms upon predisposition to longer persistence of tick-borne encephalitis virus, there is necessary to observe both promoter allelic variants of IL-4 genes, and polymorphisms of appropriate cytokine receptor genes. (Med. Immunol., vol. 10, N 4-5, pp 389-396). |
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