Targeting fibroblast CD248 attenuates CCL17-expressing macrophages and tissue fibrosis

Targeting fibroblast CD248 attenuates CCL17-expressing macrophages and tissue fibrosis

Abstract The role of fibroblasts in tissue fibrosis has been extensively studied. Activated fibroblasts, namely myofibroblasts, produce pathological extracellular matrix. CD248, a type I transmembrane glycoprotein, is expressed in fibroblasts after birth. In human chronic kidney disease, upregulated...

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Main Authors: Chen-Hsueh Pai, Shu-Rung Lin, Chia-Hao Liu, Szu-Yu Pan, Hao Hsu, Yi-Ting Chen, Ching-Tzu Yen, I-Shing Yu, Hua-Lin Wu, Shuei-Liong Lin, Shu-Wha Lin
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/965920586e02498b8ac147fc3cb3b83b
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https://doaj.org/article/965920586e02498b8ac147fc3cb3b83b

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