The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity

The expression of four pyridoxal kinase (PDXK) human variants in Drosophila impacts on genome integrity

Abstract In eukaryotes, pyridoxal kinase (PDXK) acts in vitamin B6 salvage pathway to produce pyridoxal 5′-phosphate (PLP), the active form of the vitamin, which is implicated in numerous crucial metabolic reactions. In Drosophila, mutations in the dPdxk gene cause chromosome aberrations (CABs) and...

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Main Authors: Elisa Mascolo, Anna Barile, Lorenzo Stufera Mecarelli, Noemi Amoroso, Chiara Merigliano, Arianna Massimi, Isabella Saggio, Torben Hansen, Angela Tramonti, Martino Luigi Di Salvo, Fabrizio Barbetti, Roberto Contestabile, Fiammetta Vernì
Format: article
Language:EN
Published: Nature Portfolio 2019
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/98cbd0cfb2e64e8c8b4f5fe2009a0e66
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