Identification of pyrazolopyridazinones as PDEδ inhibitors

PDEδ is a widely expressed factor that sustains the spatial organization and signalling of Ras family proteins. Here the authors describe the activity of Deltazinone 1, a new highly selective PDEδ inhibitor of KRAS-dependent cancer cell growth with low cytotoxic side effects.

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Autores principales:	Björn Papke, Sandip Murarka, Holger A Vogel, Pablo Martín-Gago, Marija Kovacevic, Dina C Truxius, Eyad K Fansa, Shehab Ismail, Gunther Zimmermann, Kaatje Heinelt, Carsten Schultz-Fademrecht, Alaa Al Saabi, Matthias Baumann, Peter Nussbaumer, Alfred Wittinghofer, Herbert Waldmann, Philippe I.H. Bastiaens
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/98e07183cd0647cabef2a5d6074729d8
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spelling	oai:doaj.org-article:98e07183cd0647cabef2a5d6074729d82021-12-02T14:40:14ZIdentification of pyrazolopyridazinones as PDEδ inhibitors10.1038/ncomms113602041-1723https://doaj.org/article/98e07183cd0647cabef2a5d6074729d82016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11360https://doaj.org/toc/2041-1723PDEδ is a widely expressed factor that sustains the spatial organization and signalling of Ras family proteins. Here the authors describe the activity of Deltazinone 1, a new highly selective PDEδ inhibitor of KRAS-dependent cancer cell growth with low cytotoxic side effects.Björn PapkeSandip MurarkaHolger A VogelPablo Martín-GagoMarija KovacevicDina C TruxiusEyad K FansaShehab IsmailGunther ZimmermannKaatje HeineltCarsten Schultz-FademrechtAlaa Al SaabiMatthias BaumannPeter NussbaumerAlfred WittinghoferHerbert WaldmannPhilippe I.H. BastiaensNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Björn Papke Sandip Murarka Holger A Vogel Pablo Martín-Gago Marija Kovacevic Dina C Truxius Eyad K Fansa Shehab Ismail Gunther Zimmermann Kaatje Heinelt Carsten Schultz-Fademrecht Alaa Al Saabi Matthias Baumann Peter Nussbaumer Alfred Wittinghofer Herbert Waldmann Philippe I.H. Bastiaens Identification of pyrazolopyridazinones as PDEδ inhibitors
description	PDEδ is a widely expressed factor that sustains the spatial organization and signalling of Ras family proteins. Here the authors describe the activity of Deltazinone 1, a new highly selective PDEδ inhibitor of KRAS-dependent cancer cell growth with low cytotoxic side effects.
format	article
author	Björn Papke Sandip Murarka Holger A Vogel Pablo Martín-Gago Marija Kovacevic Dina C Truxius Eyad K Fansa Shehab Ismail Gunther Zimmermann Kaatje Heinelt Carsten Schultz-Fademrecht Alaa Al Saabi Matthias Baumann Peter Nussbaumer Alfred Wittinghofer Herbert Waldmann Philippe I.H. Bastiaens
author_facet	Björn Papke Sandip Murarka Holger A Vogel Pablo Martín-Gago Marija Kovacevic Dina C Truxius Eyad K Fansa Shehab Ismail Gunther Zimmermann Kaatje Heinelt Carsten Schultz-Fademrecht Alaa Al Saabi Matthias Baumann Peter Nussbaumer Alfred Wittinghofer Herbert Waldmann Philippe I.H. Bastiaens
author_sort	Björn Papke
title	Identification of pyrazolopyridazinones as PDEδ inhibitors
title_short	Identification of pyrazolopyridazinones as PDEδ inhibitors
title_full	Identification of pyrazolopyridazinones as PDEδ inhibitors
title_fullStr	Identification of pyrazolopyridazinones as PDEδ inhibitors
title_full_unstemmed	Identification of pyrazolopyridazinones as PDEδ inhibitors
title_sort	identification of pyrazolopyridazinones as pdeδ inhibitors
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/98e07183cd0647cabef2a5d6074729d8
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Identification of pyrazolopyridazinones as PDEδ inhibitors

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