Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation

Aging is associated with declining protein homeostasis. Here, using a chemical mutagenesis screen for lifespan extension in C. elegans, the authors report that inhibition of the integrated stress response enhances longevity and protein homeostasis in a manner dependent on kin-35, without reducing pr...

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Autores principales: Maxime J. Derisbourg, Laura E. Wester, Ruth Baddi, Martin S. Denzel
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/9a0b16e7b2bc4663b337481e2bbfff36
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