Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation

Aging is associated with declining protein homeostasis. Here, using a chemical mutagenesis screen for lifespan extension in C. elegans, the authors report that inhibition of the integrated stress response enhances longevity and protein homeostasis in a manner dependent on kin-35, without reducing pr...

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Autores principales:	Maxime J. Derisbourg, Laura E. Wester, Ruth Baddi, Martin S. Denzel
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9a0b16e7b2bc4663b337481e2bbfff36
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spelling	oai:doaj.org-article:9a0b16e7b2bc4663b337481e2bbfff362021-12-02T13:17:39ZMutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation10.1038/s41467-021-21743-x2041-1723https://doaj.org/article/9a0b16e7b2bc4663b337481e2bbfff362021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21743-xhttps://doaj.org/toc/2041-1723Aging is associated with declining protein homeostasis. Here, using a chemical mutagenesis screen for lifespan extension in C. elegans, the authors report that inhibition of the integrated stress response enhances longevity and protein homeostasis in a manner dependent on kin-35, without reducing protein synthesis.Maxime J. DerisbourgLaura E. WesterRuth BaddiMartin S. DenzelNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maxime J. Derisbourg Laura E. Wester Ruth Baddi Martin S. Denzel Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation
description	Aging is associated with declining protein homeostasis. Here, using a chemical mutagenesis screen for lifespan extension in C. elegans, the authors report that inhibition of the integrated stress response enhances longevity and protein homeostasis in a manner dependent on kin-35, without reducing protein synthesis.
format	article
author	Maxime J. Derisbourg Laura E. Wester Ruth Baddi Martin S. Denzel
author_facet	Maxime J. Derisbourg Laura E. Wester Ruth Baddi Martin S. Denzel
author_sort	Maxime J. Derisbourg
title	Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation
title_short	Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation
title_full	Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation
title_fullStr	Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation
title_full_unstemmed	Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation
title_sort	mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mrna translation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/9a0b16e7b2bc4663b337481e2bbfff36
work_keys_str_mv	AT maximejderisbourg mutagenesisscreenuncoverslifespanextensionthroughintegratedstressresponseinhibitionwithoutreducedmrnatranslation AT lauraewester mutagenesisscreenuncoverslifespanextensionthroughintegratedstressresponseinhibitionwithoutreducedmrnatranslation AT ruthbaddi mutagenesisscreenuncoverslifespanextensionthroughintegratedstressresponseinhibitionwithoutreducedmrnatranslation AT martinsdenzel mutagenesisscreenuncoverslifespanextensionthroughintegratedstressresponseinhibitionwithoutreducedmrnatranslation
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Mutagenesis screen uncovers lifespan extension through integrated stress response inhibition without reduced mRNA translation

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