Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection

Amino acid biosynthetic pathways are an attractive alternative to treat chronic infections such as Mycobacterium tuberculosis (Mtb). Here, the authors investigate the metabolic response to disruption of the aspartate pathway in persistent Mtb and identify essential enzymes as potential new targets f...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Erik J. Hasenoehrl, Dannah Rae Sajorda, Linda Berney-Meyer, Samantha Johnson, JoAnn M. Tufariello, Tobias Fuhrer, Gregory M. Cook, William R. Jacobs, Michael Berney
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9a443ee14abc47879b6eef91b9b88f3a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:9a443ee14abc47879b6eef91b9b88f3a
record_format	dspace
spelling	oai:doaj.org-article:9a443ee14abc47879b6eef91b9b88f3a2021-12-02T17:01:27ZDerailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection10.1038/s41467-019-12224-32041-1723https://doaj.org/article/9a443ee14abc47879b6eef91b9b88f3a2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12224-3https://doaj.org/toc/2041-1723Amino acid biosynthetic pathways are an attractive alternative to treat chronic infections such as Mycobacterium tuberculosis (Mtb). Here, the authors investigate the metabolic response to disruption of the aspartate pathway in persistent Mtb and identify essential enzymes as potential new targets for drug development.Erik J. HasenoehrlDannah Rae SajordaLinda Berney-MeyerSamantha JohnsonJoAnn M. TufarielloTobias FuhrerGregory M. CookWilliam R. JacobsMichael BerneyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Erik J. Hasenoehrl Dannah Rae Sajorda Linda Berney-Meyer Samantha Johnson JoAnn M. Tufariello Tobias Fuhrer Gregory M. Cook William R. Jacobs Michael Berney Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection
description	Amino acid biosynthetic pathways are an attractive alternative to treat chronic infections such as Mycobacterium tuberculosis (Mtb). Here, the authors investigate the metabolic response to disruption of the aspartate pathway in persistent Mtb and identify essential enzymes as potential new targets for drug development.
format	article
author	Erik J. Hasenoehrl Dannah Rae Sajorda Linda Berney-Meyer Samantha Johnson JoAnn M. Tufariello Tobias Fuhrer Gregory M. Cook William R. Jacobs Michael Berney
author_facet	Erik J. Hasenoehrl Dannah Rae Sajorda Linda Berney-Meyer Samantha Johnson JoAnn M. Tufariello Tobias Fuhrer Gregory M. Cook William R. Jacobs Michael Berney
author_sort	Erik J. Hasenoehrl
title	Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection
title_short	Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection
title_full	Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection
title_fullStr	Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection
title_full_unstemmed	Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection
title_sort	derailing the aspartate pathway of mycobacterium tuberculosis to eradicate persistent infection
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/9a443ee14abc47879b6eef91b9b88f3a
work_keys_str_mv	AT erikjhasenoehrl derailingtheaspartatepathwayofmycobacteriumtuberculosistoeradicatepersistentinfection AT dannahraesajorda derailingtheaspartatepathwayofmycobacteriumtuberculosistoeradicatepersistentinfection AT lindaberneymeyer derailingtheaspartatepathwayofmycobacteriumtuberculosistoeradicatepersistentinfection AT samanthajohnson derailingtheaspartatepathwayofmycobacteriumtuberculosistoeradicatepersistentinfection AT joannmtufariello derailingtheaspartatepathwayofmycobacteriumtuberculosistoeradicatepersistentinfection AT tobiasfuhrer derailingtheaspartatepathwayofmycobacteriumtuberculosistoeradicatepersistentinfection AT gregorymcook derailingtheaspartatepathwayofmycobacteriumtuberculosistoeradicatepersistentinfection AT williamrjacobs derailingtheaspartatepathwayofmycobacteriumtuberculosistoeradicatepersistentinfection AT michaelberney derailingtheaspartatepathwayofmycobacteriumtuberculosistoeradicatepersistentinfection
_version_	1718382163367297024

Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection

Ejemplares similares