Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection

Derailing the aspartate pathway of Mycobacterium tuberculosis to eradicate persistent infection

Amino acid biosynthetic pathways are an attractive alternative to treat chronic infections such as Mycobacterium tuberculosis (Mtb). Here, the authors investigate the metabolic response to disruption of the aspartate pathway in persistent Mtb and identify essential enzymes as potential new targets f...

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Autores principales: Erik J. Hasenoehrl, Dannah Rae Sajorda, Linda Berney-Meyer, Samantha Johnson, JoAnn M. Tufariello, Tobias Fuhrer, Gregory M. Cook, William R. Jacobs, Michael Berney
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Science
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Acceso en línea:https://doaj.org/article/9a443ee14abc47879b6eef91b9b88f3a
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