Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange

Omalizumab is an antibody against IgE that is used to treat patients with asthma and chronic idiopathic urticaria. Here, the authors report the structure of omalizumab in complex with an IgE fragment and develop an approach to exchange rather than deplete IgE on human basophils to block their activa...

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Auteurs principaux: Luke F. Pennington, Svetlana Tarchevskaya, Daniel Brigger, Karthik Sathiyamoorthy, Michelle T. Graham, Kari Christine Nadeau, Alexander Eggel, Theodore S. Jardetzky
Format: article
Langue:EN
Publié: Nature Portfolio 2016
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Accès en ligne:https://doaj.org/article/9e27e301820c4ec280e87434aba9d1c7
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