Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange

Omalizumab is an antibody against IgE that is used to treat patients with asthma and chronic idiopathic urticaria. Here, the authors report the structure of omalizumab in complex with an IgE fragment and develop an approach to exchange rather than deplete IgE on human basophils to block their activa...

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Autores principales:	Luke F. Pennington, Svetlana Tarchevskaya, Daniel Brigger, Karthik Sathiyamoorthy, Michelle T. Graham, Kari Christine Nadeau, Alexander Eggel, Theodore S. Jardetzky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9e27e301820c4ec280e87434aba9d1c7
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spelling	oai:doaj.org-article:9e27e301820c4ec280e87434aba9d1c72021-12-02T15:35:22ZStructural basis of omalizumab therapy and omalizumab-mediated IgE exchange10.1038/ncomms116102041-1723https://doaj.org/article/9e27e301820c4ec280e87434aba9d1c72016-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms11610https://doaj.org/toc/2041-1723Omalizumab is an antibody against IgE that is used to treat patients with asthma and chronic idiopathic urticaria. Here, the authors report the structure of omalizumab in complex with an IgE fragment and develop an approach to exchange rather than deplete IgE on human basophils to block their activation.Luke F. PenningtonSvetlana TarchevskayaDaniel BriggerKarthik SathiyamoorthyMichelle T. GrahamKari Christine NadeauAlexander EggelTheodore S. JardetzkyNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Luke F. Pennington Svetlana Tarchevskaya Daniel Brigger Karthik Sathiyamoorthy Michelle T. Graham Kari Christine Nadeau Alexander Eggel Theodore S. Jardetzky Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange
description	Omalizumab is an antibody against IgE that is used to treat patients with asthma and chronic idiopathic urticaria. Here, the authors report the structure of omalizumab in complex with an IgE fragment and develop an approach to exchange rather than deplete IgE on human basophils to block their activation.
format	article
author	Luke F. Pennington Svetlana Tarchevskaya Daniel Brigger Karthik Sathiyamoorthy Michelle T. Graham Kari Christine Nadeau Alexander Eggel Theodore S. Jardetzky
author_facet	Luke F. Pennington Svetlana Tarchevskaya Daniel Brigger Karthik Sathiyamoorthy Michelle T. Graham Kari Christine Nadeau Alexander Eggel Theodore S. Jardetzky
author_sort	Luke F. Pennington
title	Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange
title_short	Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange
title_full	Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange
title_fullStr	Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange
title_full_unstemmed	Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange
title_sort	structural basis of omalizumab therapy and omalizumab-mediated ige exchange
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/9e27e301820c4ec280e87434aba9d1c7
work_keys_str_mv	AT lukefpennington structuralbasisofomalizumabtherapyandomalizumabmediatedigeexchange AT svetlanatarchevskaya structuralbasisofomalizumabtherapyandomalizumabmediatedigeexchange AT danielbrigger structuralbasisofomalizumabtherapyandomalizumabmediatedigeexchange AT karthiksathiyamoorthy structuralbasisofomalizumabtherapyandomalizumabmediatedigeexchange AT michelletgraham structuralbasisofomalizumabtherapyandomalizumabmediatedigeexchange AT karichristinenadeau structuralbasisofomalizumabtherapyandomalizumabmediatedigeexchange AT alexandereggel structuralbasisofomalizumabtherapyandomalizumabmediatedigeexchange AT theodoresjardetzky structuralbasisofomalizumabtherapyandomalizumabmediatedigeexchange
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Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange

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