Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling

Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling

ATRX inactivation frequently occurs in glioma. Here, the authors explore the role of ATRX inactivation in oncogenesis, highlighting ATRX deficiency driven epigenomic changes that influence the expression of genes crucial to the oncogenic phenotype.

Saved in:
Bibliographic Details
Main Authors: Carla Danussi, Promita Bose, Prasanna T. Parthasarathy, Pedro C. Silberman, John S. Van Arnam, Mark Vitucci, Oliver Y. Tang, Adriana Heguy, Yuxiang Wang, Timothy A. Chan, Gregory J. Riggins, Erik P. Sulman, Frederick Lang, Chad J. Creighton, Benjamin Deneen, C. Ryan Miller, David J. Picketts, Kasthuri Kannan, Jason T. Huse
Format: article
Language:EN
Published: Nature Portfolio 2018
Subjects:
Science
Q
Online Access:https://doaj.org/article/9ee036920a6243d48045ded2e3372a0b
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/9ee036920a6243d48045ded2e3372a0b

Similar Items