Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling

Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling

ATRX inactivation frequently occurs in glioma. Here, the authors explore the role of ATRX inactivation in oncogenesis, highlighting ATRX deficiency driven epigenomic changes that influence the expression of genes crucial to the oncogenic phenotype.

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Autores principales: Carla Danussi, Promita Bose, Prasanna T. Parthasarathy, Pedro C. Silberman, John S. Van Arnam, Mark Vitucci, Oliver Y. Tang, Adriana Heguy, Yuxiang Wang, Timothy A. Chan, Gregory J. Riggins, Erik P. Sulman, Frederick Lang, Chad J. Creighton, Benjamin Deneen, C. Ryan Miller, David J. Picketts, Kasthuri Kannan, Jason T. Huse
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/9ee036920a6243d48045ded2e3372a0b
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https://doaj.org/article/9ee036920a6243d48045ded2e3372a0b

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