Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling

ATRX inactivation frequently occurs in glioma. Here, the authors explore the role of ATRX inactivation in oncogenesis, highlighting ATRX deficiency driven epigenomic changes that influence the expression of genes crucial to the oncogenic phenotype.

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Autores principales:	Carla Danussi, Promita Bose, Prasanna T. Parthasarathy, Pedro C. Silberman, John S. Van Arnam, Mark Vitucci, Oliver Y. Tang, Adriana Heguy, Yuxiang Wang, Timothy A. Chan, Gregory J. Riggins, Erik P. Sulman, Frederick Lang, Chad J. Creighton, Benjamin Deneen, C. Ryan Miller, David J. Picketts, Kasthuri Kannan, Jason T. Huse
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/9ee036920a6243d48045ded2e3372a0b
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spelling	oai:doaj.org-article:9ee036920a6243d48045ded2e3372a0b2021-12-02T17:32:49ZAtrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling10.1038/s41467-018-03476-62041-1723https://doaj.org/article/9ee036920a6243d48045ded2e3372a0b2018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03476-6https://doaj.org/toc/2041-1723ATRX inactivation frequently occurs in glioma. Here, the authors explore the role of ATRX inactivation in oncogenesis, highlighting ATRX deficiency driven epigenomic changes that influence the expression of genes crucial to the oncogenic phenotype.Carla DanussiPromita BosePrasanna T. ParthasarathyPedro C. SilbermanJohn S. Van ArnamMark VitucciOliver Y. TangAdriana HeguyYuxiang WangTimothy A. ChanGregory J. RigginsErik P. SulmanFrederick LangChad J. CreightonBenjamin DeneenC. Ryan MillerDavid J. PickettsKasthuri KannanJason T. HuseNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Carla Danussi Promita Bose Prasanna T. Parthasarathy Pedro C. Silberman John S. Van Arnam Mark Vitucci Oliver Y. Tang Adriana Heguy Yuxiang Wang Timothy A. Chan Gregory J. Riggins Erik P. Sulman Frederick Lang Chad J. Creighton Benjamin Deneen C. Ryan Miller David J. Picketts Kasthuri Kannan Jason T. Huse Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling
description	ATRX inactivation frequently occurs in glioma. Here, the authors explore the role of ATRX inactivation in oncogenesis, highlighting ATRX deficiency driven epigenomic changes that influence the expression of genes crucial to the oncogenic phenotype.
format	article
author	Carla Danussi Promita Bose Prasanna T. Parthasarathy Pedro C. Silberman John S. Van Arnam Mark Vitucci Oliver Y. Tang Adriana Heguy Yuxiang Wang Timothy A. Chan Gregory J. Riggins Erik P. Sulman Frederick Lang Chad J. Creighton Benjamin Deneen C. Ryan Miller David J. Picketts Kasthuri Kannan Jason T. Huse
author_facet	Carla Danussi Promita Bose Prasanna T. Parthasarathy Pedro C. Silberman John S. Van Arnam Mark Vitucci Oliver Y. Tang Adriana Heguy Yuxiang Wang Timothy A. Chan Gregory J. Riggins Erik P. Sulman Frederick Lang Chad J. Creighton Benjamin Deneen C. Ryan Miller David J. Picketts Kasthuri Kannan Jason T. Huse
author_sort	Carla Danussi
title	Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling
title_short	Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling
title_full	Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling
title_fullStr	Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling
title_full_unstemmed	Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling
title_sort	atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/9ee036920a6243d48045ded2e3372a0b
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Atrx inactivation drives disease-defining phenotypes in glioma cells of origin through global epigenomic remodeling

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