On the Origin of Reverse Transcriptase-Using CRISPR-Cas Systems and Their Hyperdiverse, Enigmatic Spacer Repertoires

ABSTRACT Cas1 integrase is the key enzyme of the clustered regularly interspaced short palindromic repeat (CRISPR)-Cas adaptation module that mediates acquisition of spacers derived from foreign DNA by CRISPR arrays. In diverse bacteria, the cas1 gene is fused (or adjacent) to a gene encoding a reve...

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Auteurs principaux:	Sukrit Silas, Kira S. Makarova, Sergey Shmakov, David Páez-Espino, Georg Mohr, Yi Liu, Michelle Davison, Simon Roux, Siddharth R. Krishnamurthy, Becky Xu Hua Fu, Loren L. Hansen, David Wang, Matthew B. Sullivan, Andrew Millard, Martha R. Clokie, Devaki Bhaya, Alan M. Lambowitz, Nikos C. Kyrpides, Eugene V. Koonin, Andrew Z. Fire
Format:	article
Langue:	EN
Publié:	American Society for Microbiology 2017
Sujets:	CRISPR RNA spacer acquisition cyanobacteria deep sequencing horizontal gene transfer host-parasite relationship Microbiology QR1-502
Accès en ligne:	https://doaj.org/article/a69cf1b12c9e44f9b5265cbf1b3feb45
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On the Origin of Reverse Transcriptase-Using CRISPR-Cas Systems and Their Hyperdiverse, Enigmatic Spacer Repertoires

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