Microenvironment-derived factors driving metastatic plasticity in melanoma

Microenvironment-derived factors driving metastatic plasticity in melanoma

Phenotype switching is a form of plasticity that allows melanoma cancer cells that leave the primary tumour to invade secondary sites, to switch from an invasive to a proliferative state. Here the authors identify EDN3, and its synthetic enzyme ECE2, as a regulator of melanoma plasticity in the micr...

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Main Authors: Isabella S. Kim, Silja Heilmann, Emily R. Kansler, Yan Zhang, Milena Zimmer, Kajan Ratnakumar, Robert L. Bowman, Theresa Simon-Vermot, Myles Fennell, Ralph Garippa, Liang Lu, William Lee, Travis Hollmann, Joao B. Xavier, Richard M. White
Format: article
Language:EN
Published: Nature Portfolio 2017
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Science
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Online Access:https://doaj.org/article/a9ccb537f389465d997a19a77c63d6c9
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