Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries
Characterizing the binding selectivity landscape of interacting proteins is crucial in protein engineering. Here the authors use multi-target selective library screening and in silico next-generation sequencing to map the binding landscape of proteins and produce improved proteases inhibitors.
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Nature Portfolio
2018
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oai:doaj.org-article:ac5f05fbac774e239f296d3fd917c27a2021-12-02T16:49:37ZMapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries10.1038/s41467-018-06403-x2041-1723https://doaj.org/article/ac5f05fbac774e239f296d3fd917c27a2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06403-xhttps://doaj.org/toc/2041-1723Characterizing the binding selectivity landscape of interacting proteins is crucial in protein engineering. Here the authors use multi-target selective library screening and in silico next-generation sequencing to map the binding landscape of proteins and produce improved proteases inhibitors.Si NaftalyItay CohenAnat ShaharAlexandra HocklaEvette S. RadiskyNiv PapoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018) |
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Science Q Si Naftaly Itay Cohen Anat Shahar Alexandra Hockla Evette S. Radisky Niv Papo Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries |
description |
Characterizing the binding selectivity landscape of interacting proteins is crucial in protein engineering. Here the authors use multi-target selective library screening and in silico next-generation sequencing to map the binding landscape of proteins and produce improved proteases inhibitors. |
format |
article |
author |
Si Naftaly Itay Cohen Anat Shahar Alexandra Hockla Evette S. Radisky Niv Papo |
author_facet |
Si Naftaly Itay Cohen Anat Shahar Alexandra Hockla Evette S. Radisky Niv Papo |
author_sort |
Si Naftaly |
title |
Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries |
title_short |
Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries |
title_full |
Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries |
title_fullStr |
Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries |
title_full_unstemmed |
Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries |
title_sort |
mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/ac5f05fbac774e239f296d3fd917c27a |
work_keys_str_mv |
AT sinaftaly mappingproteinselectivitylandscapesusingmultitargetselectivescreeningandnextgenerationsequencingofcombinatoriallibraries AT itaycohen mappingproteinselectivitylandscapesusingmultitargetselectivescreeningandnextgenerationsequencingofcombinatoriallibraries AT anatshahar mappingproteinselectivitylandscapesusingmultitargetselectivescreeningandnextgenerationsequencingofcombinatoriallibraries AT alexandrahockla mappingproteinselectivitylandscapesusingmultitargetselectivescreeningandnextgenerationsequencingofcombinatoriallibraries AT evettesradisky mappingproteinselectivitylandscapesusingmultitargetselectivescreeningandnextgenerationsequencingofcombinatoriallibraries AT nivpapo mappingproteinselectivitylandscapesusingmultitargetselectivescreeningandnextgenerationsequencingofcombinatoriallibraries |
_version_ |
1718383296843350016 |