Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries

Characterizing the binding selectivity landscape of interacting proteins is crucial in protein engineering. Here the authors use multi-target selective library screening and in silico next-generation sequencing to map the binding landscape of proteins and produce improved proteases inhibitors.

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Autores principales: Si Naftaly, Itay Cohen, Anat Shahar, Alexandra Hockla, Evette S. Radisky, Niv Papo
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/ac5f05fbac774e239f296d3fd917c27a
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spelling oai:doaj.org-article:ac5f05fbac774e239f296d3fd917c27a2021-12-02T16:49:37ZMapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries10.1038/s41467-018-06403-x2041-1723https://doaj.org/article/ac5f05fbac774e239f296d3fd917c27a2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06403-xhttps://doaj.org/toc/2041-1723Characterizing the binding selectivity landscape of interacting proteins is crucial in protein engineering. Here the authors use multi-target selective library screening and in silico next-generation sequencing to map the binding landscape of proteins and produce improved proteases inhibitors.Si NaftalyItay CohenAnat ShaharAlexandra HocklaEvette S. RadiskyNiv PapoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Si Naftaly
Itay Cohen
Anat Shahar
Alexandra Hockla
Evette S. Radisky
Niv Papo
Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries
description Characterizing the binding selectivity landscape of interacting proteins is crucial in protein engineering. Here the authors use multi-target selective library screening and in silico next-generation sequencing to map the binding landscape of proteins and produce improved proteases inhibitors.
format article
author Si Naftaly
Itay Cohen
Anat Shahar
Alexandra Hockla
Evette S. Radisky
Niv Papo
author_facet Si Naftaly
Itay Cohen
Anat Shahar
Alexandra Hockla
Evette S. Radisky
Niv Papo
author_sort Si Naftaly
title Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries
title_short Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries
title_full Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries
title_fullStr Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries
title_full_unstemmed Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries
title_sort mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/ac5f05fbac774e239f296d3fd917c27a
work_keys_str_mv AT sinaftaly mappingproteinselectivitylandscapesusingmultitargetselectivescreeningandnextgenerationsequencingofcombinatoriallibraries
AT itaycohen mappingproteinselectivitylandscapesusingmultitargetselectivescreeningandnextgenerationsequencingofcombinatoriallibraries
AT anatshahar mappingproteinselectivitylandscapesusingmultitargetselectivescreeningandnextgenerationsequencingofcombinatoriallibraries
AT alexandrahockla mappingproteinselectivitylandscapesusingmultitargetselectivescreeningandnextgenerationsequencingofcombinatoriallibraries
AT evettesradisky mappingproteinselectivitylandscapesusingmultitargetselectivescreeningandnextgenerationsequencingofcombinatoriallibraries
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