Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries

Characterizing the binding selectivity landscape of interacting proteins is crucial in protein engineering. Here the authors use multi-target selective library screening and in silico next-generation sequencing to map the binding landscape of proteins and produce improved proteases inhibitors.

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Bibliographic Details
Main Authors:	Si Naftaly, Itay Cohen, Anat Shahar, Alexandra Hockla, Evette S. Radisky, Niv Papo
Format:	article
Language:	EN
Published:	Nature Portfolio 2018
Subjects:	Science Q
Online Access:	https://doaj.org/article/ac5f05fbac774e239f296d3fd917c27a
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id	oai:doaj.org-article:ac5f05fbac774e239f296d3fd917c27a
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spelling	oai:doaj.org-article:ac5f05fbac774e239f296d3fd917c27a2021-12-02T16:49:37ZMapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries10.1038/s41467-018-06403-x2041-1723https://doaj.org/article/ac5f05fbac774e239f296d3fd917c27a2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06403-xhttps://doaj.org/toc/2041-1723Characterizing the binding selectivity landscape of interacting proteins is crucial in protein engineering. Here the authors use multi-target selective library screening and in silico next-generation sequencing to map the binding landscape of proteins and produce improved proteases inhibitors.Si NaftalyItay CohenAnat ShaharAlexandra HocklaEvette S. RadiskyNiv PapoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Si Naftaly Itay Cohen Anat Shahar Alexandra Hockla Evette S. Radisky Niv Papo Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries
description	Characterizing the binding selectivity landscape of interacting proteins is crucial in protein engineering. Here the authors use multi-target selective library screening and in silico next-generation sequencing to map the binding landscape of proteins and produce improved proteases inhibitors.
format	article
author	Si Naftaly Itay Cohen Anat Shahar Alexandra Hockla Evette S. Radisky Niv Papo
author_facet	Si Naftaly Itay Cohen Anat Shahar Alexandra Hockla Evette S. Radisky Niv Papo
author_sort	Si Naftaly
title	Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries
title_short	Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries
title_full	Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries
title_fullStr	Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries
title_full_unstemmed	Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries
title_sort	mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/ac5f05fbac774e239f296d3fd917c27a
work_keys_str_mv	AT sinaftaly mappingproteinselectivitylandscapesusingmultitargetselectivescreeningandnextgenerationsequencingofcombinatoriallibraries AT itaycohen mappingproteinselectivitylandscapesusingmultitargetselectivescreeningandnextgenerationsequencingofcombinatoriallibraries AT anatshahar mappingproteinselectivitylandscapesusingmultitargetselectivescreeningandnextgenerationsequencingofcombinatoriallibraries AT alexandrahockla mappingproteinselectivitylandscapesusingmultitargetselectivescreeningandnextgenerationsequencingofcombinatoriallibraries AT evettesradisky mappingproteinselectivitylandscapesusingmultitargetselectivescreeningandnextgenerationsequencingofcombinatoriallibraries AT nivpapo mappingproteinselectivitylandscapesusingmultitargetselectivescreeningandnextgenerationsequencingofcombinatoriallibraries
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Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries

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