Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice

Mutations in SHANK2 are associated with autism spectrum disorders (ASD). Here, Peter et al. show that selective loss of Shank2in Purkinje cells of the mouse cerebellum leads to deficits in plasticity, motor behaviour, and a social behaviour phenotype similar to that seen in ASD.

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Autores principales:	Saša Peter, Michiel M. ten Brinke, Jeffrey Stedehouder, Claudia M. Reinelt, Bin Wu, Haibo Zhou, Kuikui Zhou, Henk-Jan Boele, Steven A. Kushner, Min Goo Lee, Michael J. Schmeisser, Tobias M. Boeckers, Martijn Schonewille, Freek E. Hoebeek, Chris I. De Zeeuw
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/af668473ae724b5ea8dc88a41fcf7ba7
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spelling	oai:doaj.org-article:af668473ae724b5ea8dc88a41fcf7ba72021-12-02T15:35:20ZDysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice10.1038/ncomms126272041-1723https://doaj.org/article/af668473ae724b5ea8dc88a41fcf7ba72016-09-01T00:00:00Zhttps://doi.org/10.1038/ncomms12627https://doaj.org/toc/2041-1723Mutations in SHANK2 are associated with autism spectrum disorders (ASD). Here, Peter et al. show that selective loss of Shank2in Purkinje cells of the mouse cerebellum leads to deficits in plasticity, motor behaviour, and a social behaviour phenotype similar to that seen in ASD.Saša PeterMichiel M. ten BrinkeJeffrey StedehouderClaudia M. ReineltBin WuHaibo ZhouKuikui ZhouHenk-Jan BoeleSteven A. KushnerMin Goo LeeMichael J. SchmeisserTobias M. BoeckersMartijn SchonewilleFreek E. HoebeekChris I. De ZeeuwNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Saša Peter Michiel M. ten Brinke Jeffrey Stedehouder Claudia M. Reinelt Bin Wu Haibo Zhou Kuikui Zhou Henk-Jan Boele Steven A. Kushner Min Goo Lee Michael J. Schmeisser Tobias M. Boeckers Martijn Schonewille Freek E. Hoebeek Chris I. De Zeeuw Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice
description	Mutations in SHANK2 are associated with autism spectrum disorders (ASD). Here, Peter et al. show that selective loss of Shank2in Purkinje cells of the mouse cerebellum leads to deficits in plasticity, motor behaviour, and a social behaviour phenotype similar to that seen in ASD.
format	article
author	Saša Peter Michiel M. ten Brinke Jeffrey Stedehouder Claudia M. Reinelt Bin Wu Haibo Zhou Kuikui Zhou Henk-Jan Boele Steven A. Kushner Min Goo Lee Michael J. Schmeisser Tobias M. Boeckers Martijn Schonewille Freek E. Hoebeek Chris I. De Zeeuw
author_facet	Saša Peter Michiel M. ten Brinke Jeffrey Stedehouder Claudia M. Reinelt Bin Wu Haibo Zhou Kuikui Zhou Henk-Jan Boele Steven A. Kushner Min Goo Lee Michael J. Schmeisser Tobias M. Boeckers Martijn Schonewille Freek E. Hoebeek Chris I. De Zeeuw
author_sort	Saša Peter
title	Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice
title_short	Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice
title_full	Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice
title_fullStr	Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice
title_full_unstemmed	Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice
title_sort	dysfunctional cerebellar purkinje cells contribute to autism-like behaviour in shank2-deficient mice
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/af668473ae724b5ea8dc88a41fcf7ba7
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Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice

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