Structural basis of phosphatidylcholine recognition by the C2–domain of cytosolic phospholipase A2α
Ca2+-stimulated translocation of cytosolic phospholipase A2α (cPLA2α) to the Golgi induces arachidonic acid production, the rate-limiting step in pro-inflammatory eicosanoid synthesis. Structural insights into the cPLA2α preference for phosphatidylcholine (PC)-enriched membranes have remained elusiv...
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| Main Authors: | , , , , , , , , |
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| Format: | article |
| Language: | EN |
| Published: |
eLife Sciences Publications Ltd
2019
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| Subjects: | |
| Online Access: | https://doaj.org/article/af6a1b2fae9e4f1fa435261f48886fe1 |
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