Orientation-dependent Dxz4 contacts shape the 3D structure of the inactive X chromosome

The inactive X chromosome condenses into a bipartite structure. Here the authors use cells with allelic deletions or inversions to show that the Dxz4 locus is necessary to maintain the bipartite structure and that Dxz4 orientation controls the distribution of contacts on the inactive X chromosome.

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Auteurs principaux:	G. Bonora, X. Deng, H. Fang, V. Ramani, R. Qiu, J. B. Berletch, G. N. Filippova, Z. Duan, J. Shendure, W. S. Noble, C. M. Disteche
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/afd44e04d74f45258dc5ec7a69e31b59
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spelling	oai:doaj.org-article:afd44e04d74f45258dc5ec7a69e31b592021-12-02T14:40:07ZOrientation-dependent Dxz4 contacts shape the 3D structure of the inactive X chromosome10.1038/s41467-018-03694-y2041-1723https://doaj.org/article/afd44e04d74f45258dc5ec7a69e31b592018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03694-yhttps://doaj.org/toc/2041-1723The inactive X chromosome condenses into a bipartite structure. Here the authors use cells with allelic deletions or inversions to show that the Dxz4 locus is necessary to maintain the bipartite structure and that Dxz4 orientation controls the distribution of contacts on the inactive X chromosome.G. BonoraX. DengH. FangV. RamaniR. QiuJ. B. BerletchG. N. FilippovaZ. DuanJ. ShendureW. S. NobleC. M. DistecheNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q G. Bonora X. Deng H. Fang V. Ramani R. Qiu J. B. Berletch G. N. Filippova Z. Duan J. Shendure W. S. Noble C. M. Disteche Orientation-dependent Dxz4 contacts shape the 3D structure of the inactive X chromosome
description	The inactive X chromosome condenses into a bipartite structure. Here the authors use cells with allelic deletions or inversions to show that the Dxz4 locus is necessary to maintain the bipartite structure and that Dxz4 orientation controls the distribution of contacts on the inactive X chromosome.
format	article
author	G. Bonora X. Deng H. Fang V. Ramani R. Qiu J. B. Berletch G. N. Filippova Z. Duan J. Shendure W. S. Noble C. M. Disteche
author_facet	G. Bonora X. Deng H. Fang V. Ramani R. Qiu J. B. Berletch G. N. Filippova Z. Duan J. Shendure W. S. Noble C. M. Disteche
author_sort	G. Bonora
title	Orientation-dependent Dxz4 contacts shape the 3D structure of the inactive X chromosome
title_short	Orientation-dependent Dxz4 contacts shape the 3D structure of the inactive X chromosome
title_full	Orientation-dependent Dxz4 contacts shape the 3D structure of the inactive X chromosome
title_fullStr	Orientation-dependent Dxz4 contacts shape the 3D structure of the inactive X chromosome
title_full_unstemmed	Orientation-dependent Dxz4 contacts shape the 3D structure of the inactive X chromosome
title_sort	orientation-dependent dxz4 contacts shape the 3d structure of the inactive x chromosome
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/afd44e04d74f45258dc5ec7a69e31b59
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Orientation-dependent Dxz4 contacts shape the 3D structure of the inactive X chromosome

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