Orientation-dependent Dxz4 contacts shape the 3D structure of the inactive X chromosome
The inactive X chromosome condenses into a bipartite structure. Here the authors use cells with allelic deletions or inversions to show that the Dxz4 locus is necessary to maintain the bipartite structure and that Dxz4 orientation controls the distribution of contacts on the inactive X chromosome.
Enregistré dans:
Auteurs principaux: | G. Bonora, X. Deng, H. Fang, V. Ramani, R. Qiu, J. B. Berletch, G. N. Filippova, Z. Duan, J. Shendure, W. S. Noble, C. M. Disteche |
---|---|
Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2018
|
Sujets: | |
Accès en ligne: | https://doaj.org/article/afd44e04d74f45258dc5ec7a69e31b59 |
Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
Documents similaires
-
Trans- and cis-acting effects of Firre on epigenetic features of the inactive X chromosome
par: He Fang, et autres
Publié: (2020) -
Chromosome compartments on the inactive X guide TAD formation independently of transcription during X-reactivation
par: Moritz Bauer, et autres
Publié: (2021) -
trans-Acting Factors and cis Elements Involved in the Human Inactive X Chromosome Organization and Compaction
par: Zhuo Sun, et autres
Publié: (2021) -
The non-canonical SMC protein SmcHD1 antagonises TAD formation and compartmentalisation on the inactive X chromosome
par: Michal R. Gdula, et autres
Publié: (2019) -
TAD-like single-cell domain structures exist on both active and inactive X chromosomes and persist under epigenetic perturbations
par: Yubao Cheng, et autres
Publié: (2021)