Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo

Goadsporin is an antibacterial peptide highly customized by multiple post-translational modifying enzymes. Here, the authors dissect its biosynthetic pathway byin vitro reconstitution and use their insights to produce goadsporin analogues in vitro and in vivo.

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Autores principales:	Taro Ozaki, Kona Yamashita, Yuki Goto, Morito Shimomura, Shohei Hayashi, Shumpei Asamizu, Yoshinori Sugai, Haruo Ikeda, Hiroaki Suga, Hiroyasu Onaka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b21b652ae3eb468b9440c69d70205317
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spelling	oai:doaj.org-article:b21b652ae3eb468b9440c69d702053172021-12-02T17:06:17ZDissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo10.1038/ncomms142072041-1723https://doaj.org/article/b21b652ae3eb468b9440c69d702053172017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14207https://doaj.org/toc/2041-1723Goadsporin is an antibacterial peptide highly customized by multiple post-translational modifying enzymes. Here, the authors dissect its biosynthetic pathway byin vitro reconstitution and use their insights to produce goadsporin analogues in vitro and in vivo.Taro OzakiKona YamashitaYuki GotoMorito ShimomuraShohei HayashiShumpei AsamizuYoshinori SugaiHaruo IkedaHiroaki SugaHiroyasu OnakaNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Taro Ozaki Kona Yamashita Yuki Goto Morito Shimomura Shohei Hayashi Shumpei Asamizu Yoshinori Sugai Haruo Ikeda Hiroaki Suga Hiroyasu Onaka Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo
description	Goadsporin is an antibacterial peptide highly customized by multiple post-translational modifying enzymes. Here, the authors dissect its biosynthetic pathway byin vitro reconstitution and use their insights to produce goadsporin analogues in vitro and in vivo.
format	article
author	Taro Ozaki Kona Yamashita Yuki Goto Morito Shimomura Shohei Hayashi Shumpei Asamizu Yoshinori Sugai Haruo Ikeda Hiroaki Suga Hiroyasu Onaka
author_facet	Taro Ozaki Kona Yamashita Yuki Goto Morito Shimomura Shohei Hayashi Shumpei Asamizu Yoshinori Sugai Haruo Ikeda Hiroaki Suga Hiroyasu Onaka
author_sort	Taro Ozaki
title	Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo
title_short	Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo
title_full	Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo
title_fullStr	Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo
title_full_unstemmed	Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo
title_sort	dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/b21b652ae3eb468b9440c69d70205317
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Dissection of goadsporin biosynthesis by in vitro reconstitution leading to designer analogues expressed in vivo

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