Hemiacetal-less rapamycin derivatives designed and produced by genetic engineering of a type I polyketide synthase
Abstract Engineering polyketide synthases is one of the most promising ways of producing a variety of polyketide derivatives. Exploring the undiscovered chemical space of this medicinally important class of middle molecular weight natural products will aid in the development of improved drugs in the...
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| Auteurs principaux: | , , , , , , , |
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| Format: | article |
| Langue: | EN |
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Nature Portfolio
2021
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| Accès en ligne: | https://doaj.org/article/b2430429dc1949ffa90e4ad9492f1d0d |
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