Dietary patterns, food groups and nutrients in Crohn’s disease: associations with gut and systemic inflammation

Abstract This study examined associations between dietary intake and gut and systemic inflammation assessed by fecal calprotectin ≤ or > 100 μg/mg (FCP), C-reactive protein ≤ or > 5 mg/L (CRP) and serum cytokine profiles in Crohn’s disease (CD) patients in clinical remission. A 3-month observa...

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Autores principales:	S. Ali Naqvi, Lorian M. Taylor, Remo Panaccione, Subrata Ghosh, Herman W. Barkema, Naomi Hotte, Nusrat Shommu, Sandeep Kaur, Raylene A. Reimer, Karen L. Madsen, Maitreyi Raman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/b995b4ff63304187a4936dba0bcfc8d5
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spelling	oai:doaj.org-article:b995b4ff63304187a4936dba0bcfc8d52021-12-02T14:09:01ZDietary patterns, food groups and nutrients in Crohn’s disease: associations with gut and systemic inflammation10.1038/s41598-020-80924-82045-2322https://doaj.org/article/b995b4ff63304187a4936dba0bcfc8d52021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80924-8https://doaj.org/toc/2045-2322Abstract This study examined associations between dietary intake and gut and systemic inflammation assessed by fecal calprotectin ≤ or > 100 μg/mg (FCP), C-reactive protein ≤ or > 5 mg/L (CRP) and serum cytokine profiles in Crohn’s disease (CD) patients in clinical remission. A 3-month observational study was conducted at the University of Calgary in Calgary, Alberta, Canada between 2016 and 2018 in 66 outpatients with CD in clinical remission. FCP was obtained from stool samples at baseline and 3-months and serum CRP and serum cytokines were assessed at 3-months only (n = 41). Dietary intakes were collected using 3-day food records at baseline and 3-months and categorized as: PREDIMED Mediterranean diet scores (pMDS) total and individual components, the dietary inflammatory index (DII), food groups, and common micro- and macro-nutrients. Statistical models were developed to identify relationships between dietary factors and FCP, CRP and cytokine levels. Daily intake of leafy green vegetables was associated with FCP ≤ 100 μg/mg (p < 0.05). Increasing omega 6:3 ratio was associated with CRP ≤ 5 mg/L (p = 0.02). Different cytokines were significantly associated with various dietary variables. Future studies in patients with greater disease activity should be undertaken to explore these relationships.S. Ali NaqviLorian M. TaylorRemo PanaccioneSubrata GhoshHerman W. BarkemaNaomi HotteNusrat ShommuSandeep KaurRaylene A. ReimerKaren L. MadsenMaitreyi RamanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q S. Ali Naqvi Lorian M. Taylor Remo Panaccione Subrata Ghosh Herman W. Barkema Naomi Hotte Nusrat Shommu Sandeep Kaur Raylene A. Reimer Karen L. Madsen Maitreyi Raman Dietary patterns, food groups and nutrients in Crohn’s disease: associations with gut and systemic inflammation
description	Abstract This study examined associations between dietary intake and gut and systemic inflammation assessed by fecal calprotectin ≤ or > 100 μg/mg (FCP), C-reactive protein ≤ or > 5 mg/L (CRP) and serum cytokine profiles in Crohn’s disease (CD) patients in clinical remission. A 3-month observational study was conducted at the University of Calgary in Calgary, Alberta, Canada between 2016 and 2018 in 66 outpatients with CD in clinical remission. FCP was obtained from stool samples at baseline and 3-months and serum CRP and serum cytokines were assessed at 3-months only (n = 41). Dietary intakes were collected using 3-day food records at baseline and 3-months and categorized as: PREDIMED Mediterranean diet scores (pMDS) total and individual components, the dietary inflammatory index (DII), food groups, and common micro- and macro-nutrients. Statistical models were developed to identify relationships between dietary factors and FCP, CRP and cytokine levels. Daily intake of leafy green vegetables was associated with FCP ≤ 100 μg/mg (p < 0.05). Increasing omega 6:3 ratio was associated with CRP ≤ 5 mg/L (p = 0.02). Different cytokines were significantly associated with various dietary variables. Future studies in patients with greater disease activity should be undertaken to explore these relationships.
format	article
author	S. Ali Naqvi Lorian M. Taylor Remo Panaccione Subrata Ghosh Herman W. Barkema Naomi Hotte Nusrat Shommu Sandeep Kaur Raylene A. Reimer Karen L. Madsen Maitreyi Raman
author_facet	S. Ali Naqvi Lorian M. Taylor Remo Panaccione Subrata Ghosh Herman W. Barkema Naomi Hotte Nusrat Shommu Sandeep Kaur Raylene A. Reimer Karen L. Madsen Maitreyi Raman
author_sort	S. Ali Naqvi
title	Dietary patterns, food groups and nutrients in Crohn’s disease: associations with gut and systemic inflammation
title_short	Dietary patterns, food groups and nutrients in Crohn’s disease: associations with gut and systemic inflammation
title_full	Dietary patterns, food groups and nutrients in Crohn’s disease: associations with gut and systemic inflammation
title_fullStr	Dietary patterns, food groups and nutrients in Crohn’s disease: associations with gut and systemic inflammation
title_full_unstemmed	Dietary patterns, food groups and nutrients in Crohn’s disease: associations with gut and systemic inflammation
title_sort	dietary patterns, food groups and nutrients in crohn’s disease: associations with gut and systemic inflammation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/b995b4ff63304187a4936dba0bcfc8d5
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Dietary patterns, food groups and nutrients in Crohn’s disease: associations with gut and systemic inflammation

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