Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza

A limited number of therapeutics is available to treat influenza A virus (IAV) infections. Here, the authors show that defective interfering genes, delivered with a dual-functional peptide that enables intracellular accumulation and prevents endosomal acidification, inhibit IAV replication in vitro...

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Autores principales:	Hanjun Zhao, Kelvin K. W. To, Hin Chu, Qiulu Ding, Xiaoyu Zhao, Cun Li, Huiping Shuai, Shuofeng Yuan, Jie Zhou, Kin-Hang Kok, Shibo Jiang, Kwok-Yung Yuen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/b9a90862ca3f4f30b3cd7f536f65af9d
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spelling	oai:doaj.org-article:b9a90862ca3f4f30b3cd7f536f65af9d2021-12-02T16:56:56ZDual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza10.1038/s41467-018-04792-72041-1723https://doaj.org/article/b9a90862ca3f4f30b3cd7f536f65af9d2018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04792-7https://doaj.org/toc/2041-1723A limited number of therapeutics is available to treat influenza A virus (IAV) infections. Here, the authors show that defective interfering genes, delivered with a dual-functional peptide that enables intracellular accumulation and prevents endosomal acidification, inhibit IAV replication in vitro and in vivo.Hanjun ZhaoKelvin K. W. ToHin ChuQiulu DingXiaoyu ZhaoCun LiHuiping ShuaiShuofeng YuanJie ZhouKin-Hang KokShibo JiangKwok-Yung YuenNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hanjun Zhao Kelvin K. W. To Hin Chu Qiulu Ding Xiaoyu Zhao Cun Li Huiping Shuai Shuofeng Yuan Jie Zhou Kin-Hang Kok Shibo Jiang Kwok-Yung Yuen Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza
description	A limited number of therapeutics is available to treat influenza A virus (IAV) infections. Here, the authors show that defective interfering genes, delivered with a dual-functional peptide that enables intracellular accumulation and prevents endosomal acidification, inhibit IAV replication in vitro and in vivo.
format	article
author	Hanjun Zhao Kelvin K. W. To Hin Chu Qiulu Ding Xiaoyu Zhao Cun Li Huiping Shuai Shuofeng Yuan Jie Zhou Kin-Hang Kok Shibo Jiang Kwok-Yung Yuen
author_facet	Hanjun Zhao Kelvin K. W. To Hin Chu Qiulu Ding Xiaoyu Zhao Cun Li Huiping Shuai Shuofeng Yuan Jie Zhou Kin-Hang Kok Shibo Jiang Kwok-Yung Yuen
author_sort	Hanjun Zhao
title	Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza
title_short	Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza
title_full	Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza
title_fullStr	Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza
title_full_unstemmed	Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza
title_sort	dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/b9a90862ca3f4f30b3cd7f536f65af9d
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Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza

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