Defective homologous recombination DNA repair as therapeutic target in advanced chordoma
Chordomas are rare bone tumors with limited therapeutic options. Here, the authors identify molecular alterations associated with defective homologous recombination DNA repair in advanced chordomas and report prolonged response in a patient treated with a PARP inhibitor, which later acquired resista...
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Auteurs principaux: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Format: | article |
Langue: | EN |
Publié: |
Nature Portfolio
2019
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Accès en ligne: | https://doaj.org/article/ba10289481024dc5944d84dae65732a8 |
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