Defective homologous recombination DNA repair as therapeutic target in advanced chordoma

Chordomas are rare bone tumors with limited therapeutic options. Here, the authors identify molecular alterations associated with defective homologous recombination DNA repair in advanced chordomas and report prolonged response in a patient treated with a PARP inhibitor, which later acquired resista...

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Autores principales:	Stefan Gröschel, Daniel Hübschmann, Francesco Raimondi, Peter Horak, Gregor Warsow, Martina Fröhlich, Barbara Klink, Laura Gieldon, Barbara Hutter, Kortine Kleinheinz, David Bonekamp, Oliver Marschal, Priya Chudasama, Jagoda Mika, Marie Groth, Sebastian Uhrig, Stephen Krämer, Christoph Heining, Christoph E. Heilig, Daniela Richter, Eva Reisinger, Katrin Pfütze, Roland Eils, Stephan Wolf, Christof von Kalle, Christian Brandts, Claudia Scholl, Wilko Weichert, Stephan Richter, Sebastian Bauer, Roland Penzel, Evelin Schröck, Albrecht Stenzinger, Richard F. Schlenk, Benedikt Brors, Robert B. Russell, Hanno Glimm, Matthias Schlesner, Stefan Fröhling
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/ba10289481024dc5944d84dae65732a8
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spelling	oai:doaj.org-article:ba10289481024dc5944d84dae65732a82021-12-02T14:35:50ZDefective homologous recombination DNA repair as therapeutic target in advanced chordoma10.1038/s41467-019-09633-92041-1723https://doaj.org/article/ba10289481024dc5944d84dae65732a82019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09633-9https://doaj.org/toc/2041-1723Chordomas are rare bone tumors with limited therapeutic options. Here, the authors identify molecular alterations associated with defective homologous recombination DNA repair in advanced chordomas and report prolonged response in a patient treated with a PARP inhibitor, which later acquired resistance due to a newly gained PARP1 mutation.Stefan GröschelDaniel HübschmannFrancesco RaimondiPeter HorakGregor WarsowMartina FröhlichBarbara KlinkLaura GieldonBarbara HutterKortine KleinheinzDavid BonekampOliver MarschalPriya ChudasamaJagoda MikaMarie GrothSebastian UhrigStephen KrämerChristoph HeiningChristoph E. HeiligDaniela RichterEva ReisingerKatrin PfützeRoland EilsStephan WolfChristof von KalleChristian BrandtsClaudia SchollWilko WeichertStephan RichterSebastian BauerRoland PenzelEvelin SchröckAlbrecht StenzingerRichard F. SchlenkBenedikt BrorsRobert B. RussellHanno GlimmMatthias SchlesnerStefan FröhlingNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Stefan Gröschel Daniel Hübschmann Francesco Raimondi Peter Horak Gregor Warsow Martina Fröhlich Barbara Klink Laura Gieldon Barbara Hutter Kortine Kleinheinz David Bonekamp Oliver Marschal Priya Chudasama Jagoda Mika Marie Groth Sebastian Uhrig Stephen Krämer Christoph Heining Christoph E. Heilig Daniela Richter Eva Reisinger Katrin Pfütze Roland Eils Stephan Wolf Christof von Kalle Christian Brandts Claudia Scholl Wilko Weichert Stephan Richter Sebastian Bauer Roland Penzel Evelin Schröck Albrecht Stenzinger Richard F. Schlenk Benedikt Brors Robert B. Russell Hanno Glimm Matthias Schlesner Stefan Fröhling Defective homologous recombination DNA repair as therapeutic target in advanced chordoma
description	Chordomas are rare bone tumors with limited therapeutic options. Here, the authors identify molecular alterations associated with defective homologous recombination DNA repair in advanced chordomas and report prolonged response in a patient treated with a PARP inhibitor, which later acquired resistance due to a newly gained PARP1 mutation.
format	article
author	Stefan Gröschel Daniel Hübschmann Francesco Raimondi Peter Horak Gregor Warsow Martina Fröhlich Barbara Klink Laura Gieldon Barbara Hutter Kortine Kleinheinz David Bonekamp Oliver Marschal Priya Chudasama Jagoda Mika Marie Groth Sebastian Uhrig Stephen Krämer Christoph Heining Christoph E. Heilig Daniela Richter Eva Reisinger Katrin Pfütze Roland Eils Stephan Wolf Christof von Kalle Christian Brandts Claudia Scholl Wilko Weichert Stephan Richter Sebastian Bauer Roland Penzel Evelin Schröck Albrecht Stenzinger Richard F. Schlenk Benedikt Brors Robert B. Russell Hanno Glimm Matthias Schlesner Stefan Fröhling
author_facet	Stefan Gröschel Daniel Hübschmann Francesco Raimondi Peter Horak Gregor Warsow Martina Fröhlich Barbara Klink Laura Gieldon Barbara Hutter Kortine Kleinheinz David Bonekamp Oliver Marschal Priya Chudasama Jagoda Mika Marie Groth Sebastian Uhrig Stephen Krämer Christoph Heining Christoph E. Heilig Daniela Richter Eva Reisinger Katrin Pfütze Roland Eils Stephan Wolf Christof von Kalle Christian Brandts Claudia Scholl Wilko Weichert Stephan Richter Sebastian Bauer Roland Penzel Evelin Schröck Albrecht Stenzinger Richard F. Schlenk Benedikt Brors Robert B. Russell Hanno Glimm Matthias Schlesner Stefan Fröhling
author_sort	Stefan Gröschel
title	Defective homologous recombination DNA repair as therapeutic target in advanced chordoma
title_short	Defective homologous recombination DNA repair as therapeutic target in advanced chordoma
title_full	Defective homologous recombination DNA repair as therapeutic target in advanced chordoma
title_fullStr	Defective homologous recombination DNA repair as therapeutic target in advanced chordoma
title_full_unstemmed	Defective homologous recombination DNA repair as therapeutic target in advanced chordoma
title_sort	defective homologous recombination dna repair as therapeutic target in advanced chordoma
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/ba10289481024dc5944d84dae65732a8
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Defective homologous recombination DNA repair as therapeutic target in advanced chordoma

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