Revisiting antithrombotic therapeutics; sculptin, a novel specific, competitive, reversible, scissile and tight binding inhibitor of thrombin
Abstract Thrombin is a multifunctional enzyme with a key role in the coagulation cascade. Its functional modulation can culminate into normal blood coagulation or thrombosis. Thus, the identification of novel potent inhibitors of thrombin are of immense importance. Sculptin is the first specific thr...
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Autores principales: | Asif Iqbal, Mauricio Barbugiani Goldfeder, Rafael Marques-Porto, Huma Asif, Jean Gabriel de Souza, Fernanda Faria, Ana Marisa Chudzinski-Tavassi |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2017
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Materias: | |
Acceso en línea: | https://doaj.org/article/ba1295f0327f41e988619873c275f432 |
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